The action of non-canonical Wnt signaling during tissue morphogenesis remains unclear. Here, the authors find that Dact1 promotes oligomerization of Dvl to couple its binding partner switch from Vangl to Fz with formation of a signalosome-like cluster. ...
Here, in this article the main aim is to present a cutting edge outlining of the present learning of the role of intracellular Wnt-mediated signaling system in cancer augmentation and prevention. The study shows that the subdivision into canonical and non-canonical Wnt signaling pathways solely ...
Wnt signaling is a major driver of colorectal cancers, but compounds targeting Wnt pathways are poorly tolerated. Chemical inhibition of Dishevelled–cholesterol binding selectively restricts colorectal tumor growth while sparing the normal intestinal epithelium, opening new doors for therapy. ...
The canonical Wnt signaling pathway is of paramount importance in development and disease. An emergent question is whether the upstream cascade of the canonical Wnt pathway has physiologically relevant roles beyond β-catenin-mediated transcription, which is difficult to study due to the pervasive role ...
14. Durak O, Gao F, Kaeser-Woo YJ, Rueda R, Martorell AJ, Nott A, Liu CY, Watson LA, Tsai LH. Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling. Nat Neurosci. 2016;...
(PEDF), a liver-derived soluble Wnt inhibitor, which restrains intestinal stem cell (ISC) hyperproliferation to maintain gut homeostasis by suppressing the Wnt/β-catenin signaling pathway. Furthermore, we found that microbial danger si...
Distinct Functions for Wnt/β-Catenin in Hair Follicle Stem Cell Proliferation and Survival and Interfollicular Epidermal Homeostasis Wnt/β-catenin signaling is a central regulator of adult stem cells. Variable sensitivity of Wnt reporter transgenes, β-catenins dual roles in adhesion and signaling, ...
cell signaling 2细胞信号传导.pdf,Signal Transduction Signal Transduction Part II Prof. Tianhua Zhou Department of Cell Biology Zhejiang University School of Medicine Office hours by appointment tzhou@ Key contents for signal transduction: I. Signaling mo
《Cell》最新细胞信号通路大全 Motor Proteins in Spindle Assembly and mTOR Signaling Lgr5-Wntβ-catenin信号通路对胃癌干样细胞恶性生物学行为的影响及其分子调控机制研究 奥沙利铂联合地西他滨通过Wnt_β-Catenin信号通路抑制胃癌细胞株MKN-28的机制研究 《Cell》最新细胞信号通路大全 BMP Signaling in development ...
Volumetric Compression-Increased Intracellular Crowding Promotes ISC Self-Renewal by Elevating Wnt/b-Catenin Signaling体积压缩增加的细胞内拥挤通过提升 Wnt/b-Catenin 信号传导促进 ISC 自我更新 在肠隐窝中,ISCs 在高水平的 Wnt/b-c...