The diverse and titrated responses that result from the activation of the Wnt signaling pathway however begs the question of how the Wnt signaling network integrates the various inputs that a cell receives to elicit the correct and coordinated responses. Until recently, a rationale for the ...
Stem cellOver the years, the role of the Wingless -int (Wnt) signaling pathway during embryogenesis has been the focus of many researchers, its role being fundamental for physiological organogenesis. More recently, during adulthood, the Wnt signaling pathway has been found to be involved in the ...
Limbal stem cells (LSCs), the basal layer of the limbal epithelium, are essential for maintenance of corneal epithelium structural integrity and corneal epithelial healing after damage. Wnt signaling pathway include canonical signaling pathway (namely Wnt/beta-catenin signaling pathway) and non-canonical...
原始出处: Chen Li, Zhuoquan Li, et al., The role of the Wnt/β-catenin signaling pathway in the proliferation of gold nanoparticle-treated human periodontal ligament stem cells. Stem Cell Res Ther. 2018; 9: 214 ...
10. Tang QL, et al. Salinomycin inhibits osteosarcoma by targeting itstumor stem cells. Cancer Lett. 2011 Dec 1;311(1):113-21.11. Varelas X, et al. The Hippo pathway regulatesWnt/beta-catenin signaling. Dev Cell. 2010 Apr 20;18(4):579-91.12. Lu D, et al. Salinomycin inhibits ...
Tian, H., et al., Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis. Cell Rep, 2015. 11(1): p. 33-42. 当Notch信号受到抑制,小肠干细胞倾向于分化成分泌细胞,并抑制营养吸收细胞的分化趋势。当Notch受体被特异性抗体阻断后,结果发现阻断Notch会解除Wnt途...
10. Tang QL, et al. Salinomycin inhibitsosteosarcomaby targeting itstumor stem cells. Cancer Lett. 2011 Dec 1;311(1):113-21. 11. Varelas X, et al. The Hippo pathway regulatesWnt/beta-catenin signaling. Dev Cell. 2010 Apr 20;18(4):579-91. ...
Wnt signaling is widely recognized as essential for normal and cancer stem cell. Moreover, β-catenin-dependent Wnt pathway, referred to as canonical, has gained attention, while β-catenin-independent Wnt pathways, known as non-canonical, have remained conspicuously less explored. However, recent ...
Wnt signaling is an important morphogenetic signaling pathway best known for its essential role in determining embryonic cell fates; it is often activated to re-specify fetal cells or to maintain the lineage flexibility of somatic stem cells. In this review, we consider the role of this pathway ...
factor TCF4 leads to depletion of stem cells [1]. The Wnt pathway has also been implicated as a self-renewal signal in the hematopoietic system [2, 3]. Alternatively, loss of the tumor suppressor APC or gain of β-catenin activity leads ...