Further, the plethora of molecular interactions of the pathway are supported by cell biological and biochemical experiments. The Wnt/尾-catenin signaling pathway is one of a few central signaling pathways that regulate many aspects of embryonic development. The major cellular outcomes of activation of...
然而在多种癌症细胞内发现这些 Wnt/β-catenin 通路负调控因子的基因发生突变和缺失,β-catenin 在细胞质内大量聚集随后转移至核内与 T 细胞因子/淋巴增强因子(Tcellfactor/Lymphoid enhancing factor, TCF/LEF)等转录因子形成复合物,激活下游...
Multiple Targets of the Canonical WNT/β-Catenin Signaling in Cancers. Front Oncol. 2019 Nov 18, 9: 1248. [11] Zhu D, et al. hsa-miR-199b-3p suppresses osteosarcoma progression by targeting CCDC88A, inhibiting epithelial-to-mesenchymal transition, and Wnt/beta-catenin signaling pathway. Sci...
β-catenin 在细胞质内大量聚集随后转移至核内与 T 细胞因子/淋巴增强因子 (Tcellfactor/Lymphoid enhancing factor, TCF/LEF) 等转录因子形成复合物,激活下游靶基因推动细胞周期发展或产生异常蛋白质,诱导 EMT,使细胞发生癌变[7]。
[11] Zhu D, et al. hsa-miR-199b-3p suppresses osteosarcoma progression by targeting CCDC88A, inhibiting epithelial-to-mesenchymal transition, and Wnt/beta-catenin signaling pathway. Sci Rep. 2023 Aug 2, 13(1): 12544. [12] Ling DJ, et al. MicroRNA-145 inhibits lung cancer cell metastasi...
3. Li F, Chong ZZ, Maiese K. Vital elementsof the Wnt-Frizzled signaling pathway in the nervous system. Curr NeurovascRes. 2005 Oct;2(4):331-40. PubMed ID: 16181124 4. Urano T. Wnt-beta-catenin signaling inbone metabolism. Clin C...
group domain. They are involved in the Wnt signaling pathway, particularly during embryonic [2] and stem-cell development,[3] but also had been found to play a role in cancer[4] and diabetes.[5] TCF/LEF factors recruit the coactivator beta-catenin to enhancer elements of genes they target...
在没有Wnt信号的情况下,β-catenin被含有AXIN(一种支架蛋白)、APC(adenomatous polyposis coli,结肠腺瘤息肉易感蛋白)、CK1α(casein kinase 1α,酪蛋白激酶1α)、GSK3β(glycogen synthase kinase 3β,糖原合成酶激酶3β)的多亚基复合物结合并调节,这促进了β-catenin的磷酸化及其与β-TRCP(beta-transducin repea...
3. MacDonald BT, et al. Wnt/beta-cateninsignaling: components, mechanisms, and diseases. Dev Cell. 2009Jul;17(1):9-26.4. T Zhan, etal. Wnt signaling in cancer. Oncogene. 2017 Mar;36(11):1461-1473.5. Theka I, et al. Wnt/β-catenin signaling pathway safeguards epigenetic stability ...
[11] Zhu D, et al. hsa-miR-199b-3p suppresses osteosarcoma progression by targeting CCDC88A, inhibiting epithelial-to-mesenchymal transition, and Wnt/beta-catenin signaling pathway. Sci Rep. 2023 Aug 2, 13(1): 12544. [12] Ling DJ, et al. MicroRNA-145 inhibits lung cancer cell metastasi...