在没有Wnt信号的情况下,β-catenin被含有AXIN(一种支架蛋白)、APC(adenomatous polyposis coli,结肠腺瘤息肉易感蛋白)、CK1α(casein kinase 1α,酪蛋白激酶1α)、GSK3β(glycogen synthase kinase 3β,糖原合成酶激酶3β)的多亚基复合物结合并调节,这...
The Wnt - Beta Catenin Pathway Part 1 10-1-1949 2134 4 细胞信号通路系列6一PI3K-Akt 起个昵称花10分钟 3.2万 58 Hippo信号通路 Mst1/2 Lst1/2 YAP/TAZ 勇敢术术向前冲 1385 1 Wnt_β-Catenin Signaling Pathway _ Overview, Purpose and APC Mutations (480p) tggtgg 3701 1 Notch信号通路 ...
然而在多种癌症细胞内发现这些 Wnt/β-catenin 通路负调控因子的基因发生突变和缺失,β-catenin 在细胞质内大量聚集随后转移至核内与 T 细胞因子/淋巴增强因子(Tcellfactor/Lymphoid enhancing factor, TCF/LEF)等转录因子形成复合物,激活下游...
Multiple Targets of the Canonical WNT/β-Catenin Signaling in Cancers. Front Oncol. 2019 Nov 18, 9: 1248. [11] Zhu D, et al. hsa-miR-199b-3p suppresses osteosarcoma progression by targeting CCDC88A, inhibiting epithelial-to-mesenchymal transition, and Wnt/beta-catenin signaling pathway. Sci...
[11] Zhu D, et al. hsa-miR-199b-3p suppresses osteosarcoma progression by targeting CCDC88A, inhibiting epithelial-to-mesenchymal transition, and Wnt/beta-catenin signaling pathway. Sci Rep. 2023 Aug 2, 13(1): 12544. [12] Ling DJ, et al. MicroRNA-145 inhibits lung cancer cell metastasi...
[11] Zhu D, et al. hsa-miR-199b-3p suppresses osteosarcoma progression by targeting CCDC88A, inhibiting epithelial-to-mesenchymal transition, and Wnt/beta-catenin signaling pathway. Sci Rep. 2023 Aug 2, 13(1): 12544. [12] Ling DJ, et al. MicroRNA-145 inhibits lung cancer cell metastasi...
3. MacDonald BT, et al. Wnt/beta-cateninsignaling: components, mechanisms, and diseases. Dev Cell. 2009Jul;17(1):9-26.4. T Zhan, etal. Wnt signaling in cancer. Oncogene. 2017 Mar;36(11):1461-1473.5. Theka I, et al. Wnt/β-catenin signaling pathway safeguards epigenetic stability ...
在没有Wnt信号的情况下,β-catenin被含有AXIN(一种支架蛋白)、APC(adenomatous polyposis coli,结肠腺瘤息肉易感蛋白)、CK1α(casein kinase 1α,酪蛋白激酶1α)、GSK3β(glycogen synthase kinase 3β,糖原合成酶激酶3β)的多亚基复合物结合并调节,这促进了β-catenin的磷酸化及其与β-TRCP(beta-transducin repea...
Further, the plethora of molecular interactions of the pathway are supported by cell biological and biochemical experiments. The Wnt/尾-catenin signaling pathway is one of a few central signaling pathways that regulate many aspects of embryonic development. The major cellular outcomes of activation of...
group domain. They are involved in the Wnt signaling pathway, particularly during embryonic [2] and stem-cell development,[3] but also had been found to play a role in cancer[4] and diabetes.[5] TCF/LEF factors recruit the coactivator beta-catenin to enhancer elements of genes they target...