“Since this is the first time single-cell RNA sequencing has been performed in cells of the fruit fly eye, we had to create a comprehensive map or cell atlas, accurately describing gene expression in each cell type in the normal eye. We then relied on this atlas to determine how an RB...
NeuronsGliaSingle-cell sequencingPrimatesThe steady occurrence of DNA mutations is a key source for evolution, generating the genomic variation in the population upon which natural selection acts. Mutations driving evolution have to occur in the oocytes and sperm in order to be transmitted to the ...
Explain consensus sequencing in DNA. Is DNA always six base pairs long? What will happen if a target DNA sequence lacks a terminator sequence? Why do prokaryotes need to have genetic variation? What is the difference between genome sequencing and DNA sequencing? What ...
Single cell sequencing analysis found that of the four types of fibroblasts in synovial tissue, CD55+ fibroblasts exhibited the highest expression of pain-associated genes. Located in the outer synovial lining, CD55+ cells secrete synovial fluid, allowing for frictionless joint movement. They also e...
To get these results, scientists in the Laboratory of Evolutionary Genetics and Genomics did single-cell sequencing on the RNA from the testes of about 300 fruit flies, roughly half of them young (48 hours old) and half old (25 days old), advancing a line of inquiry they began in 2019...
3B). Under this scenario, the term ‘monogenic’ refers to lineages in which the production of single-sex broods has become the dominant strategy in a population. This may occur via recombination suppression via inversions around the dominant female-determining alleles. Alternatively, inversions may ...
et al. Regulatory T cell response to low-dose interleukin-2 in ischemic heart disease. NEJM Evidence 1, EVIDoa2100009 (2021). In this phase 1b/2a study, low-dose IL-2 expanded Treg cells without adverse events of major concern, and single-cell RNA sequencing demonstrated the engagement ...
Furthermore, non-human primates can help to identify new targets and mechanisms for nucleic acid drugs by using advanced technologies, such as single-cell sequencing and in vivo imaging. Therefore, non-human primate experimental animal resources are essential for advancing the field of nucleic acid ...
human pluripotent stem cells iPSCs: Induced pluripotent stem cells KH: K homology KO: Knockout LTP: Long-term potentiation MAP1B: Microtubule associated protein 1B pre-mRNP: Pre-messenger ribonucleoprotein sc-RNAseq: Single cell RNA sequencing...
Two years ago, during discussions at an international meeting on cortical neurons in Copenhagen, participants agreed that the time was right to finally tackle the creation of a unified classification. A group of 74 scientists proposed the use of single-cell RNA sequencing as the skeleton for a ...