Whole-genome doubling (WGD) is common in human cancers, occurring early in tumorigenesis and generating genetically unstable tetraploid cells that fuel tumour development1,2. Cells that undergo WGD (WGD+ cells) must adapt to accommodate their abnormal tetraploid state; however, the nature of these ...
Whole-genome doubling (WGD) is a recurrent event in human cancers and it promotes chromosomal instability and acquisition of aneuploidies1,2,3,4,5,6,78. However, the three-dimensional organization of chromatin in WGD cells and its contribution to oncogenic phenotypes are currently unknown. Here w...
Whole-genome duplication (WGD) is an important evolutionary force in eukaryotes1,2,3,4,5,6. Nearly one-third of contemporary vascular plant species have undergone or have ancestors that have undergone WGD7. Among animals, polyploidy is less frequent but well-known cases occurred in parthenogeneti...
Whole genome duplication (WGD) is a common phenomenon in plants, inducing species diversity, promoting speciation, and playing an important role in providing new genetic material in plant evolution. So far, numerous new gene functions such as pseudogenization, neofunctionalization, and subfunctionalizatio...
Following an episode of whole genome doubling (WGD), gene duplicates are lost at an initially high rate through processes such as epigenetic silencing, pseudogenization, and deletion of chromosomal segments containing one or more genes, while intra- and inter-chromosomal rearrangement mechanisms redistri...
Surprisingly, there is little direct experimental evidence of the extent to which WGD restores the fertility of initially sterile hybrids. However, hybridization and polyploidy are often linked in the evolution of new lineages (Stebbins, 1985; Soltis and Soltis, 1989; Mandakova et al., 2013). ...
Whole genome duplication (WGD) is a major factor in evolution, adaptation and speciation. Yet by doubling the number of homologs present, WGD challenges reliable chromosome segregation, a process conserved across eukaryotes. Through its negative effects on chromosome segregation, WGD can contribute to ...
This study investigates the impact of tumor cell whole-genome doubling (WGD) on the detection of ctDNA in plasma collected preoperatively from newly diagnosed colorectal cancer (CRC) patients. Methods: WGD was estimated from copy numbers derived from whole-exome sequencing (WES) data of matched ...
Whole銈瀍nome duplication (WGD) is a dramatic, common event in plants. Because of the detrimental effects arising from doubling the entire chromosome set, such as minority cytotype exclusion, genomic instability, mitotic and meiotic abnormalities, alterations in cell architecture, or epigenetic changes...
Here, we used a genetically tractable synthetic rice segmental allotetraploid system to interrogate genome﹚ide DNA methylation and gene expression responses and outcomes to the separate and combined effects of hybridization, WGD and HEs. Progenies of the tetraploid rice were genomically diverse due to ...