Whole-genome doubling (WGD) is a recurrent event in human cancers and it promotes chromosomal instability and acquisition of aneuploidies1,2,3,4,5,6. However, the three-dimensional organization of chromatin in WGD cells and its contribution to oncogenic phenotypes are currently unknown. Here we s...
Whole-genome doubling (WGD) is common in human cancers, occurring early in tumorigenesis and generating genetically unstable tetraploid cells that fuel tumour development1,2. Cells that undergo WGD (WGD+ cells) must adapt to accommodate their abnormal tetraploid state; however, the nature of these ...
However, few studies have unveiled alternations on genome-wide expression pattern and histone modifications induced by whole-genome doubling (WGD) process. In this study, we conducted transcriptome analysis for the diploid and tetraploid Ae. taushcii lines using the leaf a...
To investigate whether hybridization could increase the probability of WGD, we measured the rate of WGD in yeast intra-lineage crosses and hybrids using MA. We propagated hundreds of parallel crosses with serial bottlenecks to measure the neutral rate of genome doubling. We eliminated the potential ...
Following an episode of whole genome doubling (WGD), gene duplicates are lost at an initially high rate through processes such as epigenetic silencing, pseudogenization, and deletion of chromosomal segments containing one or more genes, while intra- and inter-chromosomal rearrangement mechanisms redistri...
Although colchicine itself can affect the phenotype independent of its effects on chromosome doubling (Husband et al., 2008) even after two generations (Munzbergova, 2017), our results are consistent with polyploid-dependent effects. The phenotypic changes caused by increases in DNA per cell are ...
Furthermore, none of the Chinese samples showed evidence of chromothripsis and genome doubling that are often found in EAC from Western countries. In summary, Chinese EAC tumor samples had distinct genomic profiles and signatures, suggesting that EAC in Chinese individuals may arise from a different...
[67]. The doubling property suggests that doubling the number of equally common species should result in double the index value. However, this principle may not hold true with Shannon indices. Simply doubling the difference in Shannon diversity index between two conditions does not necessarily ...
Genome sequencing has revolutionized our view of the relationships among genomes, particularly in revealing the confounding effects of lateral genetic transfer (LGT). Phylogenomic techniques have been used to construct purported trees of microbial life.
The last 35 years have witnessed a doubling of global energy supplies [1]. Energy demands can only be met by reducing dependencies on fossil fuels and increasing exploration of alternate energy. First and second generation biofuels focussing on plant-derived biomass have been the subject of deba...