Full size image Conversely, treatment with the MPS1 inhibitor did not change the ploidy of the RPETP53−/−cell population (hereafter, CIN-only RPETP53−/−), but the cells exhibited a variable number of chromosomes (Fig.1c). Hence, we analysed chromatin organization before and after ...
whole-genome doublingChromosome instability is a well-known hallmark of cancer, leading to increased genetic plasticity of tumoral cells, which favors cancer aggressiveness, and poor prognosis. One of the main sources of chromosomal instability are events that lead to a Whole-Genome Duplication (WGD)...
Whole-genome doubling (WGD) is a recurrent event in human cancers and it promotes chromosomal instability and acquisition of aneuploidies1,2,3,4,5,6,7,8. However, the three-dimensional organization of chromatin in WGD cells and its contribution to oncogenic phenotypes are currently unknown. Here...
Whole-genome doubling (WGD) is common in human cancers, occurring early in tumorigenesis and generating genetically unstable tetraploid cells that fuel tumour development1,2. Cells that undergo WGD (WGD+ cells) must adapt to accommodate their abnormal tetraploid state; however, the nature of these ...
Nuclear genome sizes of 54 representative species from 44 genera of the monocot order Poales were investigated by flow cytometry. Small holoploid genomes w
Doubling genome size without polyploidization: Dynamics of retrotransposition- driven genomic expansions in Oryza australiensis, a wild relative of rice. Genome Res. 2006;16:1262–9. 29. Nystedt B, Street NR, Wetterbom A, Zuccolo A, Lin Y-C, Scofield DG, et al. The Norway spruce genome ...
Although colchicine itself can affect the phenotype independent of its effects on chromosome doubling (Husband et al., 2008) even after two generations (Munzbergova, 2017), our results are consistent with polyploid-dependent effects. The phenotypic changes caused by increases in DNA per cell are ...
But until then, Henry also said the company plans to pursue an aggressive commercial expansion, more than doubling the commercial footprint, adding commercial expertise to the executive team, and increasing the company’s digital presence.
"Changing by doubling", the impact of Whole Genome Duplications in the evolution of eukaryotes. Comptes Rendus Biologies. 2009; 332 :241–253. doi: 10.1016/j.crvi.2008.07.007. [ Cross Ref ]Jaillon O, Aury JM, Wincker P. 2009. ``Changing by doubling,'' the impact of Whole Genome ...
(FDR), we predict twice as many high-confidence ncRNA candidates inD.melanogasterwhile less than doubling the run-time. As a novelty in ncRNA prediction, we control the FDR, going beyond the usuala posterioriFDR estimation. Applying the sequence-based alignment tool Muscle for realignment, we ...