The use of whole-cell biocatalysis in ionic liquid (IL)-containing systems has attracted increasing attention in recent years. Compared to bioreactions catalyzed by isolated enzymes, the major advantage of using whole cells in biocatalytic processes is that the cells provide a natural intracellular ...
摘要: Comparison of chemical catalysis by metal complexes, enzymatic catalysis and whole-cell biocatalysis shows well-addressed advantages of the latter approach. However, a critical limitation in the pract关键词: Ionic liquids, Toxicity, Biological activity, Catalysis, Biocatalysis ...
Whole-cell biocatalysis: Evaluation of new hydrophobic ionic liquids for efficient asymmetric reduction of prochiral ketones A biphasic process design is often applied in whole-cell biocatalysis if substrate and product have low water solubility, are unstable in water or toxic fo... S Br?Utigam,D...
This format of biotransformation has been used in different biotransformation processes due to several advantages, such as high surface-area-to-volume ratio, high catalytic activity, and low energy requirements (Pinto et al., 2020; Liu et al., 2019). However, the whole-cell biocatalysis approach...
Pfruender H, Ross J, Weuster-Botz D: Water immiscible ionic liquids as solvents for whole cell biocatalysis. J Biotechnol. 2006, 124: 182-190. 10.1016/j.jbiotec.2005.12.004. Article CAS Google Scholar Kim P-Y, Pollard DJ, Woodley JM: Substrate supply for effective biocatalysis. Biotechn...
Moreover, the toxicity of the substrate resulted in a low conversion of 27.2%. Both effects were successfully prevented by in situ substrate feeding and product removal using water-immiscible ionic liquids or hydrophobic adsorbent resins. The biphasic bioreductions were optimized and the reaction ...
The connection of the ionic liquid structure to biocompatible and biocatalysis from these studies is often difficult to quantify, especially as the earliest studies often used the [PF6] and [BF4] which are now known to degrade to toxic by-products. The use of water-soluble ionic liquids was ...
Ionic liquidsToxicityBiological activityCatalysisBiocatalysisComparison of chemical catalysis by metal complexes, enzymatic catalysis and whole-cell biocatalysis shows well-addressed advantages of the latter approach. However, a critical limitation in the practical applications originates from the high sensitivity...
M. Whole-cell biocatalysis with ionic liquids. Curr. Org. Chem. 2009, 13 (13), 1242- 1258.Whole-cell biocatalysis with ionic liquids. Gangu S,Weatherley L,Scurto A. Current Organic Chemistry . 2009Gangu SA, Weatherley LR, Scurto AM. Whole-cell biocatalysis with ionic liq- uids. Curr ...
Whole-cell biocatalysis: evaluation of new hydro- phobic ionic liquids for efficient asymmetric reduction of prochiral ketones. Enzyme Microb. Technol. 45, 310-316.nbsp Whole-cell biocatalysis: Evaluation of new hydrophobic ionic liquids for efficient asymmetric reduction of prochiral ketones[J]....