Whole-genome sequencing delivers a comprehensive view, ideal for discovery applications. Newer genome sequencers perform WGS more rapidly than ever.
Keep up with all the latest news from the UK and around the world by following Sky News Tap here Through its Genomic Medicine Service, NHS England already offers whole genome sequencing for any child diagnosed with cancer, but it's not routinely used by most hospitals. The researchers conclude...
Pilot whole genome sequencing service: Bupa becomes first UK major private healthcare provider to pilot whole genome sequencing forselected UK customers, identifying risk of disease across more than 36 conditions including 10 cancers ·‘My Genomic Health’ begins as a two-year pilot offering more t...
The clinical accuracy of whole genome sequencing to detect repeat expansions was prospectively examined in previously genetically tested and undiagnosed patients recruited in 2013-17 to the 100000 Genomes Project in the UK, who were suspected of having a genetic neurological disorder (familial or early...
Over the past several years, clinicians, patients and families in the UK have witnessed a dramatic change in the way genetic testing is performed, with the introduction of whole genome sequencing (WGS) and the NHS Genomic Test Directory in 2018 [1,2]. In addition to WGS becoming more access...
We examined the feasibility of using whole-genome sequencing (WGS) data to design tumour-specific polymerase chain reaction (PCR)-based MRD tests (WGS-MRD) in 18 children with high-risk relapsed cancer, including ALL, high-risk neuroblastoma (HR-NB) and Ewing sarcoma (EWS) (n = 6 eac...
Whole genome sequencing (WGS) is becoming the preferred method for molecular genetic diagnosis of rare and unknown diseases and for identification of actionable cancer drivers. Compared to other molecular genetic methods, WGS captures most genomic variat
The whole-genome resequencing data was generated for the samples from 36 wild mice by Illumina technology. Approximately 1.4 Tb data was acquired. Raw sequencing data for the 36 wild mice ranged from 24.4 to 54.3 Gb (Additional file1: Table S3). After mapping to the mouse reference genome (...
Sequencing. The bioinformatics workflow for WGS falls into the following steps: (1) raw read quality control; (2) data preprocessing; (3) alignment; (4) variant calling; (5)genome assembly; (6)genome annotation; (7) other advanced analyses based on your research interest such as phylogenetic...
Blood lipids are heritable modifiable causal factors for coronary artery disease. Despite well-described monogenic and polygenic bases of dyslipidemia, limitations remain in discovery of lipid-associated alleles using whole genome sequencing (WGS), partl