Whole genome sequencing has emerged as the new diagnostic to reliably predict drug resistance within a clinically relevant time frame, and its deployment will have the greatest impact on TB control in highly endemic regions. To evaluate the mutations leading to drug resistance and to assess for ...
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Mycobacterium tuberculosis whole genome sequencing provides insights into the Manila strain and drug-resistance mutations in the PhilippinesThe Philippines has a high incidence of tuberculosis disease (TB), with an increasing prevalence of multidrug-resistant(MDR-TB) strains making its control difficult. ...
we generated a total of 1.57 Tb clean paired-end new data. In our previousRangiferwhole genome data comprising 23 animals7and pooled here to the present new data,
The whole-genome resequencing data was generated for the samples from 36 wild mice by Illumina technology. Approximately 1.4 Tb data was acquired. Raw sequencing data for the 36 wild mice ranged from 24.4 to 54.3 Gb (Additional file1: Table S3). After mapping to the mouse reference genome (...
Abbreviations BCG: Bacillus Calmette–Guérin; CT: Computed tomography; Mtb: Mycobacterium tuberculosis; RFLP: Restriction fragment length polymorphism; SNP: Single nucleotide polymorphism; TB: Tuberculosis; WGS: Whole genome sequencing; WHO: World Health Organization Acknowledgements We acknowledge all the ...
Mycobacterium tuberculosis and whole-genome sequencing: how close are we to unleashing its full potential? Clin. Microbiol. Infect. 24, 604–609 (2018).An extensive review of the literature outlining the potential of WGS for TB research and clinical use. CAS PubMed Google Scholar Lipworth, S...
A dataset of 1.2 Tb was obtained through pair-end sequencing. The raw data were quality-filtered using fastp software (version 0.19.8) with default parameters [10]. Clean sequencing reads were mapped to the yak reference genome (BosGru 3.0) [7] using the BWA-MEM function (version 0.7.17...
About 4.1 Tb of whole-genome sequencing data (27.3 billion paired-end raw reads) were generated for 472 Vitis accessions and four other closely-related species at an average depth of ~15.5× (Supplementary Fig. 1). The mapping rate of these raw reads to the V. vinifera reference genome12...
Whole genome sequencing (WGS) is becoming the preferred method for molecular genetic diagnosis of rare and unknown diseases and for identification of actionable cancer drivers. Compared to other molecular genetic methods, WGS captures most genomic variat