Whole genome sequencing (WGS) is the comprehensive read and analysis of an entire genome, including non-coding regions of the genome.
Nik-Zainal, S., et al., Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature, 2016. 534(7605): p. 47-54.研究人员测了560位乳腺癌患者(556位女性和4位男性)的肿瘤和正常组织的全基因组,共鉴定出93个驱动基因,以及与缺陷DNA修复和BRCA1及BRCA2功能相关的突变标签(...
Whole-genome sequencing delivers a comprehensive view, ideal for discovery applications. Newer genome sequencers perform WGS more rapidly than ever.
23. However, genome-wide genetic divergence has never been quantified. We calculated the average pairwise sequence differences (dXY) between species and compareddXYagainst heterozygosity, finding that the two distributions partially overlap (Fig.1b). Thus, the sequence...
Robin Gasser and his colleagues report the whole-genome sequence of Schistosoma haematobium. They include comparisons to the genome sequences of S. mansoni and S. japonicum, the two other species that cause schistosomiasis in humans. Schistosomiasis is a
Sequencing (NGS), has revolutionized the field, enabling the analysis of entire genomes in a fast and cost-effective manner [7,8]. At this stage the last hard-to-sequence bits of the human genome have been mapped, and hundreds of thousands of people have had their entire genome sequenced ...
genomeindividualized medicinethe past 60 years have witnessed remarkable progress in genetics and genomics from the description of the dna double helix by watson and crick to the release of the first draft sequence of the human genome in 2001 and the successful completion of the human genome ...
whole genome sequencing in laboratories worldwide, which effectively ushered in a new era of biological discovery. The power of the approach has been realized in the study of human populations andhuman diseasessuch ascancer, as well as in the elucidation of whole genome sequences of cropplants,...
and 16 samples ofM. m. castaneus(Additional file1: Fig. S1 and Table S1). The genome sequences of 36 inbred laboratory mice were downloaded from the Sanger Institute website [24] and include 29 classical inbred strains and 7 wild-derived inbred strains (Additional file1: Fig. S1 and Tabl...
4) complete genomic sequence 全基因组序列 1. In this study, the complete genomic sequences of two TuMV isolates and one TVBMV isolate, and the 3′-terminal genome sequence of one BtMV isolate were determined. 本研究克隆了2个TuMV分离物和1个TVBMV分离物的全基因组序列,分析了这2种马铃薯Y...