Different studies now suggest that, besides SARS-CoV and HCoV-NL63, ACE2 is also the host co-receptor for SARS-CoV-2 (Fig. 1). In in vitro studies, using HeLa cells with and without human ACE2 expression, Zhou et al. showed that the novel 2019 coronavirus can only infect those cells...
All viruses need to invade the cells of a host organism in order to replicate and survive. However, different cells use different mechanisms to invade the cell. Some bond with different types of receptors on the surface of the cell, while others use unique mechanisms to penetrate the cell mem...
I think that the scariest atypical cells are atypical squamous cells, the ones that show up on Pap smears. What makes them so scary is that they can be caused by so many things, including an excess of some nutrients, like B3, or a deficiency in others like folic acid. ...
By studying the 3-D structure of AIF, the team first identified the molecular pocket that looked like a potential PAR binding site. They then swapped that region out for a different one to see if it indeed took up PAR. Using HeLa cells in addition to mouse nerve and skin cells, the sc...
Infection of Hela cells or mouse embryonic fibroblasts (MEFs) with MVA resulted in the upregulation of dual specificity phosphatase 1 (DUSP1), a MAPK dephosphorylating enzyme [192]. Infection of DUSP1 knockout mice with MVA enhanced the production of pro-inflammatory cytokines indicating that DU...
A brief review of the history of cancer research makes one wonder if modern strategies for treating patients with solid tumors may sometimes cause more harm than benefit. Keywords: cancer therapy; intratumor heterogeneity; polyploid giant cancer cells; senescence; apoptosis; anastasis; immune system; ...
I think that the scariest atypical cells are atypical squamous cells, the ones that show up on Pap smears. What makes them so scary is that they can be caused by so many things, including an excess of some nutrients, like B3, or a deficiency in others like folic acid. ...
By studying the 3-D structure of AIF, the team first identified the molecular pocket that looked like a potential PAR binding site. They then swapped that region out for a different one to see if it indeed took up PAR. Using HeLa cells in addition to mouse nerve and skin cells, the sc...
This could be due to the fact that the migration of cranial-neural-crest cells (CNCCs) is related to PACS1 [1]. An experimental model of the PACS1-NDD of forebrain organoids has been developed (PACS1(+/R203W)), besides the knock-out of the PACS1 gene (PACS1(-/-)). Gene ...