Several different aspects of the immune response are altered during aging. Of those, changes in T-cell mediated response are the most studied and best described. Due to gradual thymic involution with aging, production of naive T cells is decreased, resulting in a limited diversity of T-cell re...
Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways. Proc. Natl Acad. Sci. USA 97, 12513–12518 (2000). Article CAS PubMed PubMed Central Google Scholar Wies, E. et al. The viral interferon-...
Goodwin, E. C. & DiMaio, D. Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways.Proc. Natl Acad. Sci. USA97, 12513–12518 (2000). ArticleCASPubMedPubMed CentralGoogle Scholar Wies, E. et al. The ...
In HeLa cells, disrupting the GAL-7/Bcl2 complex sensitizes cells to an apoptotic cell death [26]. Such carbohydrate-independent functions of galectins represent a paradigm shift in our comprehension of their biological activity, obliging us to rethink our strategies to inhibit their protumorigenic ...
However, there is general problem with metabolic biomarkers, the "metabolites" are generic, and that is there is no tumor unique metabolite. All metabolites are potentially present in all cells as energy, signaling, or structural elements. Also, the altered tumor metabolism shifts the fluxes ...