A handy rule to remember for this purpose is the following: the conjugate base is always a better nucleophile. 3. Electronegativity: Across The Periodic Table, Nucleophilicity Increases With Decreasing Electronegativity Assuming an atom has a pair of electrons to donate, the ability of a species to...
Because nitrogen is a litle less electronegative than oxygen,ammonia is a better nucleophile than water. This substitution works even better than the substitution of water for a halide. However, there are other problems. Ammonia is nucleophilic, but it is also basic. Which is the least acid? A...
Why is lidocaine a better nucleophile than diethylamine? Give one reason why ^{13} C NMR is less sensitive than ^1 H NMR spectroscopy. Why the presence of H_2SO_4 is essential for the nitration of chlorobenzene? Explain with the aid of a mechanism. Why is it important to inject the ...
2. Explain how solubility tests could be used to differentiate between: a. a phenol and a carboxylic acid. b. a phenol that contains electron-withdrawing groups and a phenol that contains electron-d Why is lidocaine a better nucleophile than diethylamine? Explain why pure dried benzoic ac...
a. Electronegativity of the atom possessing the hydrogen. b. Resonance stabilization of the anionic conjugate base. c. Inductive stabilization of the anionic conjugate base. d. Hybridization of the atom possessing the hydrogen. e. The atomic size of...
After the strand passage event, the DNA is re-ligated in the reversible reaction, where the free 3′-OH group of the DNA acts as a nucleophile. For this transesterification reaction, divalent cations are required (usually magnesium), which are coordinated by conserved residues of the TOPRIM ...