A type V intermediate filament protein in the nucleus that is mutated in several human dystrophies and at least one severe progeria. Cell senescence The phenomenon in which replicatively dividing cells enter a non-dividing or quiescent phase that is accompanied by changes in gene transcription and...
More recently, it has been shown that C. elegans lacking rad51 display a striking difference across the AP axis characterized by a loss of survival in the posterior half (Barghouth et al., 2018). In case of Drosophila, it is known that an IR-induced delay in developmental patterning in ...
Which part of the gene would need to have a variant or mutation for the resulting protein to be truncated (shorter) How does a DNA-binding protein regulate its own expression? What is the difference between a gene and a genetic code? Is the gene the instructions...
The ubiquitin–proteasome system (UPS) is a potential therapeutic target of a variety of tumors, such as multiple myeloma [20], hepatocellular carcinoma [21], and acute myeloid leukemia [22]. Mechanistically, the ubiquitin-activating enzyme (E1) activates the C-terminal glycine residue of ubiquiti...
Gene 366:39–50 Article PubMed CAS Google Scholar Eijpe M, Offenberg H, Goedecke W, Heyting C (2000) Localisation of RAD50 and MRE11 in spermatocyte nuclei of mouse and rat. Chromosoma 109:123–132 Article PubMed CAS Google Scholar Escalier D, Garchon HJ (2000) XMR is associated...
Breast cancer (BC) is the second leading cause of cancer-related death in women under the age of 40 years worldwide. In addition, the incidence of breast cancer in young women (BCYW) has been rising. Young women are not the focus of screening programs and BC in younger women tends to...
Sex-based differences in bronchial asthma can already be observed in childhood, at which time allergic atopic asthma is more frequently found in boys than in girls. In adulthood, higher prevalence of asthma is reported in women, especially for the more severe neutrophilic subtype associated with ob...
Positive effect of single nucleotide RAD51 135G>C polymorphism and low Ku70 protein expression on female rectal cancer patients survival after preoperative radiotherapy There are two major mechanisms for DSBs repair which are called homologous recombination and NHEJ. The NHEJ is the main pathway to ...
This is now recognized as a variant form of Brooke-Spiegler syndrome (spiradenoma, cylindroma, and trichoepithelioma) caused by germline mutation in the CYLD gene. Skin Adnexal Tumors in Plain Language: A Practical Approach for the General Surgical Pathologist Szell, "Phenotype-genotype correlation...
Differential gene expressions of the MAPK signaling pathway in enterovirus 71-infected rhabdomyosarcoma cells It is clear that the meiosis specific kinase MEK1 plays a role in ensuring interhomolog binding through its interaction with RAD54 and RAD51 [39, 40]. Potential role of meiosis proteins in...