A type V intermediate filament protein in the nucleus that is mutated in several human dystrophies and at least one severe progeria. Cell senescence The phenomenon in which replicatively dividing cells enter a non-dividing or quiescent phase that is accompanied by changes in gene transcription and...
More recently, it has been shown that C. elegans lacking rad51 display a striking difference across the AP axis characterized by a loss of survival in the posterior half (Barghouth et al., 2018). In case of Drosophila, it is known that an IR-induced delay in developmental patterning in ...
et al. REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase. J. Bacteriol. 171, 5659–5667 (1989). Article CAS PubMed PubMed Central Google Scholar Masutani, C. et al. The XPV (xeroderma pigmentosum...
Dotted lines correspond to newly synthesized DNA and are colored to match the template. Pink and gray boxes are regions of hetDNA and gene conversion, respectively. The canonical DSBR pathway, in which both broken ends engage a repair template, is shown in the center. Cleavage of the two ...
Chamutal Bornstein , Ran Brosh , Alina Molchadsky , Shalom Madar , Ira Kogan-Sakin , Ido Goldstein , Deepavali Chakravarti , Elsa R. Flores , Naomi Goldfinger , Rachel Sarig , Varda RotterSPATA18, a spermatogenesis-associated gene, is a novel transcriptional target of p53 and p63Molecular ...
the function of HR regarding intact DPCs is lacking. The involvement of HR in repair of intact DPCs likely depends on the formation of DSBs near DPCs. One example for this is the MRE11, RAD50, and NBS1 (MRN) complex [51], which is an important nuclease complex in the initiation of ...
Single-cell RNA sequencing (scRNA-seq) is a tool for studying gene expression at the single-cell level that has been widely used due to its unprecedented high resolution. In the present review, we outline the preparation process and sequencing platforms for the scRNA-seq analysis of solid tumor...
Which part of the gene would need to have a variant or mutation for the resulting protein to be truncated (shorter) How does a DNA-binding protein regulate its own expression? What is the difference between a gene and a genetic code? Is the gene the instructions ...
In ovarian cancer patients, negative family history was more frequent in those with 300T > G BRCA1 gene mutation than in 5382insC carriers. This finding indicates the necessity of searching for 300T > G mutation in families with a single diagnosis of ovarian cancer in [the] family …’ ...
E1B 55K/496R is translated starting from an internal translation initiation site and spliced at the intron to the 3′ UTR. Only the E1B 22S transcript and two major isoforms are shown. E4: The E4 gene and all seven major E4 protein products are shown. E4 contains multiple ORFs that ...