RAD51C is primarily an ovarian cancer susceptibility gene. A mutation is present in approximately 1% of unselected ovarian cancers. Among mutation carriers, the lifetime risk of ovarian cancer is approximately 9%. The average age at onset is approximately 60鈥墆ears; this suggests that preventive...
Mutation of the RAD51C gene in a Fanconi anemia-like disorder. Nat Genet 2010; 42: 406–409. Article CAS Google Scholar Dosanjh M . Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes. Nucleic Acids Res 1998; 26: 1179–1184. Article CAS...
Table S1. RAD51C SGE functional classifications, scores, and annotations, related to STAR Methods Table S2. RAD51C SGE functional classifications, scores, and annotations: expanded annotations, related to STAR Methods Data S1. Additional tables, including pairwise statistical analysis outputs, ROC/...
Mutation screening of RAD51C in high-risk breast and ovarian cancer families BRCA2 mutations. The nine exons of the RAD51C gene containing protein coding sequence were screened for mutations in genomic DNA from family probands by hi... W Lu,X Wang,H Lin,... - 《Familial Cancer》 被引...
RAD51/靶点背景介绍 RAD51基因,定位于第15号染色体,含有9个外显子和8个内含子,编码一条由339个氨基酸组成的多肽;RAD51首次被报道的时间为1993年,由ogawaH等人克隆,是真核生物体内的一种DNA重组酶。 图1.1 RAD51存在的两种二聚体形态 RAD51同系物有XRCC2、XRCC3、RAD51B(RAD51L1)、RAD51C(RAD51L2)和RAD...
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RAD51, XRCC3, and XRCC2 mutation screening in Finnish breast cancer families Liisa M. Pelttari, Johanna I. Kiiski, Salla Ranta, Sara Vilske, Carl Blomqvist, Kristiina Aittomäki, Heli Nevanlinna Corresponding author: Heli Nevanlinna, Department of Obstetrics and Gynecology, Univers...
The central recombination enzyme RAD51 has been implicated in replication fork processing and restart in response to replication stress. Here, we use a separation-of-function allele of RAD51 that retains DNA binding, but not D-loop activity, to reveal me
A knock-out mutation of Rad51C was generated previously in DT40 chicken B-lymphocyte cells (25). The mutant cells showed elevated spontaneous chromosomal aberrations, high sensitivity to killing by the cross-linking agent mitomycin C (MMC), mild sensitivity to γ-rays, and defective Rad51 ...
A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. RecA in Escherichia coli and its homolog, ScRad51 in Saccharomyces cerevisiae, are known to be essential for recombinational repair. The homolog of RecA an... DS Lim,P Hasty - 《Molec...