GENETIC mutationThe MRE11A-RAD50-NBS1 complex activates the ataxia-telangiectasia mutated (ATM) pathway and plays a central role in genome homeostasis. The association of RAD50 mutations with disease remains unclear; hence, we adopted a medaka rad50 mutant to demonstrate the significance of RAD50...
(rad50telomerase, xrs2telomerase ormre11telomerase) show the same loss of viability in culture as telomerase single mutants. Alleles ofrad50have been isolated in a genetic screen and shown to be synthetically lethal with acdc13allele22. Therad51telomerase,rad54telomerase orrad57telomerase double ...
Genomic instability and cancer have been shown to develop in cells with genetic mutations affecting the proteins in the MRN complex (2). ATM-dependent phosphorylation of Rad50 at Ser635 in response to DNA damage is important in regulating downstream signaling, DNA repair, and checkpoint control (...
Combining pathway reconstitution in electron microscopy, biochemical assays and genetic studies, we show that S. cerevisiae Mre11-Rad50 with or without Xrs2 forms higher-order assemblies in solution and on DNA. Rad50 mediates such oligomerization, and mutations in a conserved Rad50 beta-sheet ...
And its association with RAD 50 mutation is not known. Case presentation: We are reporting a 42 year old lady who was evaluated for a breast lump and was incidentally found to have a renal lesion. She underwent surgery for both and was found to have a T1c breast tumour and a renal ...
Mutations in the MRN complex, including RAD50 is implicated in tumorigenicity. For example, mutation in RAD50 was reported to be significantly associated with endometrioid endometrial carcinoma31. In breast cancer, RAD50 mutations is not associated with increased risk, but it is associated with ...
Mutations in the MRN complex, including RAD50 is implicated in tumorigenicity. For example, mutation in RAD50 was reported to be significantly associated with endometrioid endometrial carcinoma31. In breast cancer, RAD50 mutations is not associated with increased risk, but it is associated with ...
6A). In contrast, neither 15 mg/kg nor 50 mg/kg, CP-23 PO decreased TNBC tumor burden as a single agent treatment or offered dramatic tumor diminishment in combination with olaparib (50 mg/kg, PO) (Supplemental Fig. 2A). Thus, we stopped this experiment after 21 days. Only CP-8 ...
Since RAD54 is a recombinational protein associated with RAD51, this is the first genetic evidence that cancer arises from a defect in repair processes involving homologous recombination. 展开 关键词:RAD54 cancer mutation 年份: 1999 收藏 引用 批量引用 报错 分享 ...
Background The members of MRE11/RAD50/NBN (MRN) protein complex participates in DNA double-strand break repair and DNA-damage checkpoint activation. We have previously shown that the p.I171V NBN gene mutation may contribute to the development of laryngeal cancer. This study tested the hypothesis...