To the Editor Failures to repair DNA double-strand breaks (DSBs) inevitably result in the accumulation of mutations and may lead to genome instability and consequently to an elevated risk of cancer. The RAD50 gene product is a part of the MRE11 / RAD50 /NBN (M/R/N) protein complex invo...
Deletion of the RAD50 gene is a common event particularly in basal-like breast cancer, and often occurs together with deletions of BRCA1 , RB1, TP53, PTEN , and INPP4B . In this study, we investigate whether these co-deleted genes have interactive effects on survival in breast cancer. ...
For TEM, circular 5.3 kbp-long pFBDM (Addgene; Fig. 1b-iii and Supplementary Fig. 1f), linear 2.7 kbp-long pUC19 with free 4 nt-overhangs or a 2.8 kbp-long, pUC19-derived linear plasmid with streptavidin-blocked ends were used. Where indicated, circular, relaxed or linear 2.7 kbp-long...
1.Breast Cancer Res Treat. 2010 Sep;123(2):607-9. 2.Dis Markers. 2008;24(2):127-34. Specification AliasesNBSLD; RAD502; hRad50 Entrez GeneID10111 SwissprotQ92878 clone5A8E5 WB Predicted band size154kDa Host/IsotypeMouse IgG1
The MRE11–RAD50–NBS1 (MRN) complex is critical for genomic stability. Although germline mutations in MRN may increase breast cancer susceptibility, such mutations are extremely rare. Here, we have conducted a comprehensive clinicopathological study of
Breast cancer 1 gene (BRCA1) is one of the most implicated genes in hereditary breast and ovarian cancers. The BARD1 gene is a BRCA1-associated RING domain 1 protein coding gene, which interacts with BRCA1 to repair damaged DNA40. Both of BARD1 and BRCA1 participates in homologous recombi...
Entrez Gene ID: (Human) 10111, (Mouse) 19360, (Rat) 64012 功能 single-stranded DNA endodeoxyribonuclease activity DNA binding double-stranded telomeric DNA binding ATP-dependent DNA helicase activity adenylate kinase activity protein binding ATP binding 3'-5' exonuclease activity protein binding, ...
RAD50 genegermline mutationbreast cancersurvivalBackground: The prevalence of BRCA1 somatic mutations status in triple-negative breast cancer (TNBC) has not been well documented. The aims of this study were to determine the frequency of BRCA1 somatic mutations and to investigate the association ...
The recommendations for follow-up and screening are not clear for patients with a pathogenic variant of the gene. This case is presented for its rarity. 展开 关键词: BREAST RENAL cancer NUCLEOTIDE sequencing GERM cells BREAST cancer BREAST tumors ...
Breast cancer 1 gene (BRCA1) is one of the most implicated genes in hereditary breast and ovarian cancers. The BARD1 gene is a BRCA1-associated RING domain 1 protein coding gene, which interacts with BRCA1 to repair damaged DNA40. Both of BARD1 and BRCA1 participates in homologous recombi...