253: What is the association between insulin sensitivity and microarray differential gene expression in omental tissue of healthy non-obese pregnant women?Objective To determine correlations between insulin sensitivity and gene expression in omental tissue...
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The success of gene therapy using a RNA interference approach relies on small interfering RNA (siRNA) expression from a highly tissue-specific RNA polymerase II promoter rather than from ubiquitous RNA polymerase III. Accordingly, we have developed a prostate-specific vector that expresses siRNAs from...
A biosimilar is not considered a “generic” in the same way that a traditional, small molecule drug (for example: ibuprofen or acetaminophen) is determined to be a generic. Biosimilars are "similar" because they are biologics that do not have to be exact copies of the active ingredient, as...
High dietary acid load is associated with insulin resistance: the Furukawa Nutrition and Health Study. Clin Nutr. 2016;35:453–9. CAS PubMed Google Scholar Moghadam SK, Bahadoran Z, Mirmiran P, Tohidi M, Azizi F. Association between dietary acid load and insulin resistance: Tehran Lipid ...
Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele The IDDM2 type 1 diabetes susceptibility locus was mapped to and identified as allelic variation at the insulin gene (INS) VNTR regulatory polymorphism. In... ST Bennett,AJ Wilson,L Esposit...
A type V intermediate filament protein in the nucleus that is mutated in several human dystrophies and at least one severe progeria. Cell senescence The phenomenon in which replicatively dividing cells enter a non-dividing or quiescent phase that is accompanied by changes in gene transcription and...
Variants in the human insulin gene that affect pre-mRNA splicing: is -23HphI a functional single nucleotide polymorphism at IDDM2? Predisposition to type 1 diabetes and juvenile obesity is influenced by the susceptibility locus IDDM2 that includes the insulin gene (INS). Although the r... Jana...
While cancer is one of the worst, regularly eating the cancer causing foods in our top ten list can also lead to heart disease, diabetes, chronic inflammation, and so much more. What Causes Cancer? Understanding possible causes of cancer comes down to understanding the causes of gene and DNA...
Palmitoleic acid is richest in macadamia nuts, synergizes with Omega-3s (found in fish), and can help improve serum lipids ( 6), decrease inflammation ( 7), and increase insulin sensitivity ( 8). Omega-7 palmitoleic acid is also the founding member of the class of hormones called “lip...