What is the key player in TDP-43 pathol- ogy in ALS: disappearance from the nucleus or inclusion formation in the cytoplasm? Neurol. Clin Neurosci 2013; 1 (1): 11-17.Onodera O, Sugai A, Konno T, Tada M, Koyama A, Nishizawa M: What is the key player in TDP-43 pathology in ALS...
The exploration of new drug delivery routes to break through the blood-brain barrier is bringing hope for the future to the FTD patient community and their families. Promising New Advances in FTD Reprogrammed iPSCs Transactivation DNA-binding Protein 43 (TDP-43), mutations have been associated ...
Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset motor neuron disease that results from the progressive loss of motor neurons in the brainstem and spinal cord, and of upper motor neurons in the motor cortex. TDP-43 was the first protein identified in ALS. It is present in cytoplasm...
HDAC6 and protein aggregates Protein folding inside cells is not always a spontaneous event. Many synthesized proteins need a complex biological machinery in the cell to achieve their efficient conformation. Large proteins may refold inefficiently, resulting in misfolded intermediates that tend to aggreg...
Our account of "interpretability" is consistent with uses in the machine learning literature, in keeping with the philosophy of explana- tion and understanding, and pays special attention to medical artificial intelligence systems. Keywords Interpretability · Explainability · XAI · Medical AI 1 ...
Conversely, by skipping proteolysis top-down proteomics (TDP) directly analyzes proteoforms with all of their specific sets of genetic and chemical modifications intact, and virtually eliminates protein inference [4]. However, TDP is an inherently difficult approach to the characterization of a proteome...
While it is assumed by many investigators that immunopositive ubiquitin staining in Parkinson's-associated Lewy bodies represents the presence of elevated levels of intracellular ubiquitin-protein conjugates, this has yet to be definitively proven. Increases in oxidative stress along with decreased levels...
And could this be leading to some of the difficulty the field has experienced in deciding “which is right and which is an illusion” in the tau-PET literature? Let us look at some examples. To be fair, although the majority of these examples focus on [F-18]AV-1451 (AKA: flortaucip...
The role of curcumin treatment in ALS has been observed also using NSC-34 cells transfected with the DNA-RNA binding protein TDP-43. TDP-43 is one of the major disease proteins in the pathological inclusions of ALS, and it has been associated with both gain- and loss-of-function ...
neurovascular unit, mitochondrial, endoplasmic reticulum and DNA damage, protein aggregation and misfolding, and other effects. Exposure to ambient PM2.5concentrations at or below current US standards can increase the risk for TIAs, ischemic and hemorrhagic stroke, cognitive deficits, dementia, and ...