This is a syngeneic rat model developed in the same way as other glioblastoma models used in immune competent animals, with ENU treatment of pregnant female rats where the offspring develop CNS tumors; in the same way as for example the RG2 model[13]. The tumor grows in an infiltrative ...
Osteolytic Breast Cancer Causes Skeletal Muscle Weakness in an Immunocompetent Syngeneic Mouse Model. Front. Endocrinol. (Lausanne) 2017, 8, 358. [CrossRef] 141. Waning, D.L.; Mohammad, K.S.; Reiken, S.; Xie, W.; Andersson, D.C.; John, S.; Chiechi, A.; Wrig...
PDGFRβ is a novel marker of stromal activation in oral squa- mous cell carcinoma [83]. In a xenograft mouse model of lung cancer, PDGFRα has been shown to promote the recruitment of fibroblasts to the tumor infiltra- tion front. PDGFRα/βhigh CAFs have also been linked to lymph node...
Despite decades of research to understand the biological effects of ionising radiation, there is still much uncertainty over the role of dose rate. Motivated by a virtual workshop on the “Effects of spatial and temporal variation in dose delivery” organised in November 2020 by the Multidisciplinar...
but T cell therapies have shown activity in mice models and in selected clinical applications. For example, adoptive transfer of telomerase-specific T cells was studied in a syngeneic PC murine model [63]. T cells were producedin vitroby coculturing human lymphocytes with telomerase peptide-pulsed...
Mitochondrial transplantation is a promising solution for the heart following ischemia–reperfusion injury due to its capacity to replace damaged mitochondria and restore cardiac function. However, many barriers (such as inadequate mitochondrial internalization, poor survival of transplanted mitochondria, few ...
Veliparib dihydrochloride, also known as ABT-888 dihydrochloride, is a potent inhibitor of PARP1 and PARP2 with Ki values of 5.2 nM and 2.9 nM, respec..
Transimmunization restores immune surveillance and prevents recurrence in a syngeneic mouse model of ovarian cancer. Oncoimmunology 2020, 9, 1758869. [Google Scholar] [CrossRef] Blandin, A.-F.; Renner, G.; Lehmann, M.; Lelong-Rebel, I.; Martin, S.; Dontenwill, M. β1 Integrins as ...
The challenge of tumor heterogeneity–different phenotypes of cancer stem cells in a head and neck squamous cell carcinoma xenograft mouse model. Vivo 2012, 26, 593–598. [Google Scholar] Gomez-Casal, R.; Bhattacharya, C.; Ganesh, N.; Bailey, L.; Basse, P.; Gibson, M.; Epperly, M....
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