Syngeneic mouse models are in vivo models in which tumor cells from the same genetic background as the host mouse are implanted, allowing the study of cancer in an immunocompetent environment. These models are used to assess immune responses, evaluate cancer therapies, and study tumor-immune inte...
Syngeneic mouse models are used for efficacy testing of immuno-oncologic drugs and the investigation of the effects of conventional anti-cancer drugs on the immune system. In a syngeneic model, the tumor tissue was obtained from a mouse of the same genetic background as the immuno-competent reci...
Figure 1: Diagram of syngeneic mouse models. Tumor tissue of the same (murine) genetic background is implanted into a mouse with an intact native immune system. Cancer Types Spotlight Lung Cell Lines Breast Cell Lines Colon Cell Lines
These tumor models are very simplistic cancer models, but recent reports have, however, indicated that the different inoculated cancer cell lines can lead to the formation of unique tumor microenvironments (TMEs). To gain more knowledge from studies based on syngeneic tumor models, it is essential...
Syngeneic Models Syngeneic models involve implantation of available mouse tumor cell lines into immunocompetent mice of the same genetic background to conduct in vivo efficacy evaluation of potential cancer immunotherapy. Case: Validation of EMT6 tumorigenic capacity in BALB/c mice...
syngeneic immunocompetent mouse modelnext-generation sequencingco-culturetumor immune microenvironmentmultiplex immunohistochemistryThe lack of reliable animal models to assess the safety and efficacy of drugs and to explore the underlying molecular mechanisms is one of the most severe impediments in head and...
Mouse models in oncoimmunology. Nat Rev Cancer. 2016 Dec;16(12):759-773. 5.吕秋军.生物技术药物免疫性的评价和面临的挑战[J].中国新药杂志,2007(03):181-188 6.Aarden L, Ruuls SR, Wolbink G. Immunogenicity of anti-tumor necrosis factor antibodies-toward improved methods of anti-antibody ...
Recent findings have positioned tumor mutation-derived neoepitopes as attractive targets for cancer immunotherapy. Cancer vaccines that deliver neoepitopes via various vaccine formulations have demonstrated promising preliminary results in patients and a
Immune cells play critical functions in cancer, and mice with intact immune systems are vital to understanding tumor immunology. Both genetically engineered mouse models (GEMMs) and syngeneic cell transplant approaches use immunocompetent mice to define
Testing murine surrogate immuno-oncology agents requires a competent mouse immune system. This means that these POC studies can be carried out using syngeneic models ormurine tumor cell lineswithin an immunocompetent host. Why Use Syngeneic Models for POC Studies?