This section provides a quick introduction of the PDB (Protein Data Bank), which is a database for the three-dimensional structural data of large biological molecules, such as proteins and nucleic acids.
cellranger mkfastqdemultiplexes raw base call (BCL) files generated by Illumina sequencers into FASTQ files. It is a wrapper around Illumina's bcl2fastq, with additional useful features that are specific to 10x libraries and a simplified sample sheet format. cellranger counttakes FASTQ files fr...
Provides a quick introduction of NGS (Next-Generation Sequencing), which randomly breaks patient's sample into millions of DNA fragments, reads fragments as nucleotide strings, then digitally align them to a reference genome sequence to construct patient's genome sequence.©...
We now have access to a wealth of methods to design proteins, allowing protein designers to generate sequences, structures, or both at unprecedented rates2. Yet the design of functional proteins from scratch remains challenging. While this abundance of new techniques has generated global excitement ...
Distributed systems consist of multiple devices that work together to perform a task that is beyond the capacity of a single system.
them to process sequential data, such as text, in a massively parallel fashion without losing their understanding of the sequences. That parallel processing of sequential data is among the key characteristics that makes ChatGPT able to respond so quickly and well to plainspoken conversational ...
As a cell prepares to build a new protein, its DNA unzips to expose one strand of the gene with the instructions to build said protein. Then, an enzyme zooms in and constructs a new RNA molecule whose sequence mirrors that of the unzipped gene. This RNA copy, called messenger RNA (mRNA...
Transformers also played a central role in Google Deepmind'sAlphaFold 2model, which can generate protein structures from sequences of amino acids. This ability to produce original data, rather than simply analyzing existing data is why these models are known as "generative AI." ...
As a cell prepares to build a new protein, its DNA unzips to expose one strand of the gene with the instructions to build said protein. Then, an enzyme zooms in and constructs a new RNA molecule whose sequence mirrors that of the unzipped gene. This RNA copy, called messenger RNA (mRNA...
We report the discovery of the smallest peptide sequence "Cysteine-Glutamine-Tryptophan-Tryptophan" that is not found in over half-a-million curated protein sequences in the Uniprot (Swiss-Prot) database. Additionally, we report a library of 83605 pentapeptides that are not found in any of ...