Bone metastases are more frequently seen as a complication of cancer than primary bone tumors. For example, it can be seen in as many as 70% of advanced stage breast and prostate cancer cases. Metastatic bone disease is generally categorized as osteoblastic, and osteolytic disease. However most...
Among them, the most commonly diagnosed is conventional OS, which can be osteoblastic, chondroblastic or fibroblastic depending on the histology. OS principally arises from the metaphysis regions of the long bones where there is active bone remodelling, suggesting that the initial onset of this ...
Osteoblastic Factors Produced by Breast Cancer Cells Although breast cancer is primarily osteolytic, the metastatic lesion can also result in a build-up of bone, which is also harmful. In these cases, breast cancer cells likely secrete factors that influence osteoblast function that results in bone...
also showed that the mutational direction of oligometastatic and polymetastatic disease is different. Oligometastatic status is characterized by the loss of K-Ras and SMAD4 mutations (regressive mutational evolution), whereas a progressive mutational evolution with gain in K-Ras, SMAD4, B-Raf, and ...