Osteolytic metastasesOsteoblastic metastasesOsteoclastsOsteoblastsVicious cyclePre-metastatic nicheTGFβPTHrPRANKLSome of the most common cancer types have a propensity to metastasize to bone. When cancer metastasizes to bone, it causes osteolysis and abnormal new bone formation. The phenotypes of ...
The IGR-CaP1 xenograft model recapitulates mixed osteolytic/blastic bone lesions observed in metastatic prostate cancer. Bone metastases have a devastating impact on quality of life and bone pain in patients with prostate cancer and decrease survival. Animal models are import... N Al Nakouzi,O Baw...
81 - MP-08.14: Eradication of osteoblastic and osteolytic skeletal metastases of hormone refractory prostate cancer (mHRPC) after treatment with pegylated trispecific disulfide linked Fv (sdFv) targeting epitopes of EGFR, PTHrP and RANKL conjugated covalently with SATA to vinorelbine tartrate - EM|...
As such, this study aimed to develop a low complexity semiautomated multimodal μCT/μMR based approach to segment rat vertebral structure affected by mixed osteolytic/osteoblastic destruction. METHODS: Mixed vertebral metastases were developed via intracardiac injection of Ace-1 canine prostate cancer...
Semiquantitative assessment of osteoblastic, osteolytic, and mixed lytic-sclerotic bone lesions on fluorodeoxyglucose positron emission tomography/computed... Bone scintigraphy is widely used to detect bone metastases, particularly osteoblastic ones, and F-18 fluorodeoxyglucose (FDG) positron emission ...
1 Conversely, the clinical co-targeting of osteoclasts, responsible for a fraction of osteolytic metastases, has indicated that osteoclasts only had a secondary role in prostate cancer progression. Clinical trials with agents such as zolenodrate or denosumab, which inhibit osteoclast activity, showed ...
There is presently a controversy on the clinical significance of osteoblastic bone metastases in breast cancer which are not detected on FDG-PET. It has been suggested that these radiologically dense lesions represent the result of successful treatment of initially osteolytic lesions. We report a ...
A cell that produces the collagen needed for the development of new bone. As new bone grows and hardens, osteoblasts become embedded in the bone matrix. Once embedded, they are no longer able to secrete collagen and are called osteocytes. ...
In contrast, osteolytic metastases typically show strong hyperintense signals on STIR sequences, while osteoblastic metastases show similar signal behavior to hematopoietic islands due to a lack of water protons [14]. Thus, T2-weighted and STIR sequences do not help differentiate focal hematopoietic ...
Bone metastasis is a multistep process that includes cancer cell dissemination, colonization, and metastatic growth. Furthermore, this process involves complex, reciprocal interactions between cancer cells and the bone microenvironment. Bone resorption is known to be involved in both osteolytic and osteo...