Of the patients with osteoblastic metastatic disease, five showed asymptomatic, osteoblastic disease; this response was considered to be a healing response to chemotherapy. These five patients were continued on the same therapy. The median duration of this response to the adjuvant chemotherapy was 29 ...
metastatic microenvironment with stronger upregulation of androgen receptor,alkaline phosphatase,and dopa decarboxylase,as seen in the transition towards resistance.The unique microtissues engineered here represent a substantial asset to determine the involvement of the human bone microenvironment in prostate ...
Bone metastasis is a multistep process that includes cancer cell dissemination, colonization, and metastatic growth. Furthermore, this process involves complex, reciprocal interactions between cancer cells and the bone microenvironment. Bone resorption is known to be involved in both osteolytic and osteo...
While stromal interactions are essential in cancer adaptation to hormonal therapies, the effects of bone stroma and androgen deprivation on cancer progression in bone are poorly understood. Here, we tissue-engineered and validated an in vitro microtissue
Osteoma is an absolutely benign bone lesion that may arise within a bone or the periosteum. This is a lesion that can grow like a tumor or can be a local reaction, with osseous overgrowth from trauma, infection or an invading tumor such as a meningioma.
to bone tropism of luminal breast cancer. Single-cell RNA sequencing analysis reveals osteoblastic enrichment by SCUBE2 in early bone-metastatic niches. SCUBE2 facilitates release of tumor membrane-anchored SHH to activate Hedgehog signaling in mesenchymal stem cells, thus promoting osteoblast ...
摘要: OBJECTIVE. The purpose of this study was to determ 关键词:attenuation bone island CT enostosis osteoblastic metastatic disease sclerotic 被引量: 2 年份: 2016 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 radiology.jp (全网免费下载) ajronline.org (全网免费下载) ...
Metastatic bone disease: Clinical and therapeutic aspects Breast and prostate carcinomas are the tumors most commonly associated with skeletal metastases, and the skeleton is the most common site of metastatic dis... Body,J J. - 《Bone》 被引量: 233发表: 1992年 ERK 1,2 and p38 pathways ...
More severe and diffuse forms can be related to chronic anemias (particularly hematolytic types) and benign and malignant infiltrative bone marrow disorders, such as Gaucher disease, myelofibrosis, myeloma, and lymphoma, leukemia, and metastatic disease [2, 5, 6]. Besides, hematopoietic marrow ...
Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However, whether miRNAs mediate osteoclast-directed osteoblastic bone formation is m