K) Medications. The use of nonsteroidal anti-inflammatory medications (NSAIDs), beta-blockers, chemotherapeutic agents, and the compound nicorandil have all been suggested as being risk factors for canker sore outbreaks. A biological explanation for this phenomenon....
Nicorandil, a mitochondrial potassium-channel opener, has been shown to improve microvascular perfuson in patients with STEMI when given before reperfusion (19, 20). Sodium-hydrogen pump inhibitors block intracellular calcium overload; however, large multicenter trials have not shown clinical benefit as...
Nicorandil used in cardiac disease and anti-inflammatory drugs such as aspirin, ibuprofen, etc. can produce ulcers that resemble canker sores. When you suspect that your canker sores are caused by taking these drugs, consult your doctor about changing your drugs first. 15. Environmental Factors Wh...