UsesNicorandil is a vasodilator used for the prophylaxis and treatment of angina. This medication widens blood vessels thus increasing the blood and oxygen flow to the heart. It is not currently available in the US. Nicorandil is a nitric oxide donor and ATP-sensitive potassium channel opener. ...
Acute toxicity LD50 rat (mg/kg): 1200-1300 orally, 800-1000 intravenously. Originator Chugai (Japan) Uses Nicorandil is a vasodilator used for the prophylaxis and treatment of angina. This medication widens blood vessels thus increasing the blood and oxygen flow to the heart. It is not ...
Adult male Sprague-Dawley rats (n=50) were equally randomized into group 1 (sham control), group 2 [MCT (60 mg/kg i.p.)], group 3 [MCT-Nicorandil (5.0 mg/kg/day)], group 4 [MCT-Colchicine (1.0 mg/kg/day)], and group 5 (MCT-Nicorandil-Colchicine). Drugs were given on day ...
MPO, which is considered a marker of inflammation and neutrophil infiltration, uses the produced hydrogen peroxide to generate potent oxidant hypochlorite which can cause direct cytotoxicity (Abdelrahman and Abdel-Rahman 2019; Adams et al. 2010; Du et al. 2016). In APAP model, oxidative stress ...