She was hospitalised for percutaneous coronary intervention on August 31, 2009. In order to confirm ticlopidine-related liver injury, drug-lymphocyte stimulation examinations were conducted to all drugs excluding sirolimus, and showed positive findings for aspirin and nicrorandil.EBSCO_AspReactions Weekly...
Nicorandil, a nicotinamide derivative, is an orally efficacious antianginal drug possessing a nitrate moiety in its chemical structure. This drug is an effective and well-tolerated treatment for various types of angina pectoris. Its general efficacy is similar to that of nitrates, with several ...
In order to confirm ticlopidine-related liver injury, drug-lymphocyte stimulation examinations were conducted to all drugs excluding sirolimus, and showed positive findings for aspirin and nicrorandil.doi:10.2165/00128415-200912780-00026NoneSpringer International PublishingReactions Weekly...
The pathogenesis of this rare side-effect is largely unknown, but mechanisms such as the 'vascular steal phenomenon' and the direct toxic effect of the drug or its metabolites have been implicated.doi:10.1111/j.1464-410X.2010.09463.xTet Yap...
The in vitro release data and drug release mechanism of the optimized formulation followed the Higuchi kinetics and nonfickain type respectively. It can be concluded that the wet granulation is found suitable for the sustained delivery of Nicorandil over the direct compression method. Psyllium husk,...
Our findings indicate that the regional difference in nicorandil-induced vasodilation was caused neither by the K+-channel opening nor by the nitrate-like mechanism of action, but could be due to a direct Ca2+-influx blocking effect of the drug....
According to EUROPA study, the incidence of angina is high in type II diabetics. Gliclazide, a second generation sulphonylurea derivative is widely used in the treatment of type-II diabetes and is known to release insulin by K + channel inhibition. Nicorandil, a newer antianginal drug widely...