In the current study, the vasodilator and tolerance-inducing actions of a recently developed organic nitrate vasodilator, nicorandil, were compared to nitroglycerin (NTG) in an isolated coronary artery preparation. The order of potency for relaxing U46619-constricted bovine-isolated coronary artery rings...
Nicorandil (NIC), a hybrid of potassium channel opener and nitrate, has cardioprotective effects in human and various animal models of ischaemia. We previously showed that ischaemic preconditioning (IP) abolishes the protection afforded by preoperative NIC in an isolated human atrial muscle preparation,...
(1000 mol 11) increased the efflux rate constant, whereas isoprenaline (1 mol 11) was without effect.10It is concluded that nicorandil-induced relaxation does not involve the activation of -adrenoceptors but is partly attributable to the formation of nitric oxide from the nitrate moiety in its ...
nicorandil, and sodium nitroprusside was undertaken. In spite of this, the patient's state did not enhance, and they exhibited resistance towards the treatment regimen. Prolonged low cardiac function, coupled with the complications of pneumonia, resulted in the patient's death. Intracoronary vasodilato...
(SG-86) and 2-nicotinamidoethyl nitrate (nicorandil; SG-75) to reveal any structure-activity relationships.SG-209 and nicorandil caused concentration-dependent relaxation in preparations precontracted with phenylephrine (10 7 mol/l), while SG-86 produced a relaxation only at very high ...