In comparative trials involving a total of 84 patients who received nicorandil, the incidence of headache was similar to that produced by isosorbide mononitrate and isosorbide dinitrate. Headache was most frequent on initiating therapy but declined with continued treatment. To date, approximately 5% of...
The efficacy of nifedipine gastrointestinal therapeutic system (GITS), 60–90 mg o.d., isosorbide dinitrate, 40–60 mg b.d., and isosorbide mononitrate slo... J.M. Walker and P.V.L. Curry and A.E. Bailey and S.E. Steare - 《International Journal of Cardiology》 被引量: 25发表:...
Isosorbide-2-mononitrate reduces the consequences of myocardial ischaemia, including arrhythmia severity: implications for preconditioning. The effects of the intracoronary administration of isosorbide-2-mononitrate (ISMN; 3 microg kg(-1) min(-1)), a major metabolite of isosorbide dinitrate, we... K...
withdrawal of renin angiotensin aldosterone system inhibitors, serious adverse events, and other concerned adverse events within 24 weeks.ConclusionThis pilot trial will compare the preliminary effects of nicorandil, diltiazem, and isosorbide mononitrate on angiographic and clinical outcomes in patients who ...
In comparative trials involving a total of 84 patients who received nicorandil, the incidence of headache was similar to that produced by isosorbide mononitrate and isosorbide dinitrate. Headache was most frequent on initiating therapy but declined with continued treatment. To date, approximately 5% of...
Around that time period, his nicorandil dosage had been doubled [ indication, route and dosages not stated ]. He had been taking nicorandil for 8 years [ duration of treatment to reaction onset not clearly stated ]. Nicorandil replacement with isosorbide mononitrate was advised, and nicorandil ...
Nicorandil 10 or 20mg, administered orally twice daily, has well established antianginal efficacy that is similar to other nitrates (isosorbide di- and mononitrate), β-adrenoceptor antagonists (metoprolol, propranolol and atenolol) and calcium channel antagonists (diltiazem, amlodipine and nifedipine)....
In randomised, double-blind comparative studies in patients with angina pectoris, nicorandil has demonstrated equivalent efficacy, as measured by exercise tolerance testing, to isosorbide di- and mononitrate, metoprolol, propranolol, atenolol, diltiazem, amlodipine and nifedipine. The effects of nicorandil ...
Concomitant medications included atenolol, clopidogrel, diltiazem, furosemide, isosorbide mononitrate, lansoprazole and simvastatin. A defunctioning sigmoid colostomy was unsuccessful and he received tacrolimus ointment and systemic corticosteroids with little improvement. He was slowly weaned off nicorandil and,...
On presentation, she had three vuvlar ulcers and a well-defined peristomal ulcer. Two months after isosorbide mononitrate was substituted for nicorandil, the ulcers had healed. A colostomy for colovaginal fistula was performed in an 82-year-old woman, as well as drainage of an abscess in ...