Tram B. Cat PharmD, BCPS, Xi Liu-DeRyke PharmD, in Critical Care Nursing Clinics of North America, 2010 Other pharmacologic agents that have been studied for prophylactic therapy include nitrates and spironolactone. Isosorbide mononitrate (ISMN) is a potent veno- and arterial vasodilator, which...
Isosorbide dinitrateundergoes extensive first-pass metabolism in the liver and is cleared at a rate of 2 to 4 L/minute with a serum half-life of about 1 hour. Isosorbide dinitrate's clearance is primarily by denitration to the 2-mononitrate (15 to 25%) and the 5-mononitrate (75 to 85%...