Efficient cell-mediated immunity hinders tuberculosis infection by permanently arresting the infection at latent or persistent stage, but if the initial infection in the lung is not controlled or if the immune system becomes weakened, Mycobacterium tuberculosis can cause active pulmonary or extra ...
TGF-β is a key regulator of MMP expression in mice models of lung fibrosis, in particular limiting the activity of MMP-2 and MMP-9, which contributes to the aberrant accumulation of ECM proteins [85,86]. MMP-9 has also been shown to induce TGF-β production in human airway epithelium ...
Focusing the anterior chamber angle is a principal management strategy for PACG. Treatments to open the angle or halt the angle closure process such as laser peripheral iridotomy and/or iridoplasty, as well as cataract extraction, are proving their effectiveness. PACG may be preventable in the ...
The complement system is a set of immune proteins involved in first-line defense against pathogens and removal of waste materials. Recent evidence has implicated the complement cascade in diseases involving the central nervous system, including schizophrenia. Here, we provide an up-to-date narrative ...
Deterioration in the nutritional status of the patient is a common consequence of chronic degenerative diseases and worsens the prognosis [4]. On the other hand, forced nutrition distinguishes anorexia from cachexia since the latter cannot be counteracted by enteral or parenteral n...
Shi MD, Shih YW, Lee YS, Cheng YF, Tsai LY . Suppression of 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 breast adenocarcinoma cells invasion/migration by alpha-tomatine through activating PKCalpha/ERK/NF-kappaB-dependent MMP-2/MMP-9 expressions.Cell Biochem Biophys2013;66: 161–174. ...
Melatonin has been widely studied for its role in photoperiodism in seasonal breeders; it is also a potent antioxidant. Ubiquitin, a protein also widesprea
Strongin Both PA63 and PA83 are endocytosed within an anthrax protective antigen mixed heptamer: a putative mechanism to overcome a furin deficiency Arch. Biochem. Biophys., 446 (1) (2006), pp. 52-59 Google Scholar [35] I. Chvyrkova, X.C. Zhang, S. Terzyan Lethal factor of ...
CRISPR technology has the ability to facilitate a breakthrough in our understanding of the more common and complex human diseases, including rheumatic diseases The potential of CRISPR/Cas9 technology in the development of new treatment strategies is confidently expected to have a major effect on the ...
[77]. Women with CSTs III and IV therefore exhibit a higher ratio of L- to D-lactate, which can lead to increased expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and activation of matrix metalloproteinase (MMP-) 8. This expression could feasibly lead to altered cervical ...