Overexpression of Mmp2E258A, a catalytically inactive and dominant negative form of Mmp218, induced weaker phenotypic changes than Mmp2 overexpression. However, overexpression of Mmp2GPI-, in which the GPI-anchored domain of Mmp2 is removed, caused phenotypic changes similar to those induced by ...
Full size image HDAC6 regulates a subset of IL-1-induced genes in SW1353 To discover the spectrum of chondrocyte genes regulated by HDAC6 Illumina whole genome microarrays were performed following HDAC6 RNAi in combination with IL-1 stimulation (Fig. 2A,B, Supplementary Dataset 1–2). Depletio...
The patient was first seen in the FOP clinic at The University of Pennsylvania as an asymptomatic 21-year-old man (patient-R). He was the product of a full-term pregnancy and a caesarian section delivery due to a nuchal cord. Short malformed great toes and thumbs with absence of interpha...
Copper oxide nanoparticles (Nano-CuO) are one of the most produced and used nanomaterials. Previous studies have shown that exposure to Nano-CuO caused acute lung injury, inflammation, and fibrosis. However, the mechanisms underlying Nano-CuO-induced lun
In blade IV, MT1-MMP and most MT2-MMP sequences widen the motif to the full bilayer-binding EPGYPK peptide sequence, which is modified in MT3- and MT5-MMP sequences by an Arg replacement of the Lys (Figures 3D and S4B). The crystal structure of the HPX domain of MT1-MMP differs ...
Download: Download full-size image Fig. 1. Putative transcription factor biding sites in the MMP14 promoter region including the (a) g. -1723 bp A > C, (b) g. -871 bp - > T and (c) g. -831 bp A > G. The SNPs were predicted to alter the bindings of tr...
Serum-starved VSMCs were treated with each form of PAHs for 24 h. All values are represented as mean ± SD. *P < 0.05, **P < 0.01, and ***P < 0.001 versus control; #P < 0.05 and ##P < 0.01 oxy-PAHs versus PAHs; NS, no significance Full size ...
Discuss the refractive development of young rabbits under different light intensities (15000lux, 500lux, 5lux, full spectrum light, color temperature 6000k), and observe the matrix metal PROTEASE-2 (Matrix Metalloproteinase-2, MMP- 2) expression, to initially explore the mechanism by which light ...
Full size image Ameloblasts extend finger-like projections to penetrate the basement membrane and this occurs in Amelx −/− and Mmp20 −/− mice In wild-type mice, disruption of the basement membrane between pre-ameloblasts and pre-odontoblasts occurs near the apical end of the inciso...
Full size image When other immune or involution parameters of bovine mammary gland were assessed, only in very few instances the active rMMP-9 nanoparticles had a slightly different performance compared to the inactive rMMP-9 form. Concretely, BSA levels were greater at days 1 and 6 in quarter...