These patients are on high dose prednisone for the chronic GVHD which they have but the steroid is not effective, or there is an attempt to reduce the dosage or eliminate prednisone completely. This phase 1 clinical trial is hoping to see is the effect can reduce/eliminate the prednisone ...
What is small cell lung cancer? Small cell lung cancer (SCLC), sometimes referred to as "oat-cell carcinoma," occurs when the cells in your lungs start to grow unusually or uncontrollably. This unusual growth takes place inside your lungs or the lining of the airways. As more cancer cells...
graft-versus-host disease (GVHDgraft-versus-leukemia (GVL) effectmixed chimerismacute leukemiaReduced-intensity stem cell transplantation (RIST) has been shown to be a safe and useful alternative transplant method for patients including elderly and medically unfit patients. RIST conditioning regimens ...
Abnormal tumor microenvironment and immune escape in multiple myeloma (MM) are associated with regulatory T cells (Tregs), which play an important role in maintaining self-tolerance and regulating the overall immune response to infection or tumor cells.
cancer cells, it’s imperative that hematologists and oncologists understand how these new therapies work and how to use them. In this OncLive Peer Exchange, I’ll be joined by a panel of experts to discuss how the newest immunotherapies will be integrated into modern care of patients with ...
He undergoes a non-myelolablative allogeneic SCT while in first CR from a 10/10 matched unrelated donor. His post-transplant course is complicated by stage III gut and skin GVHD which resolves with escalation of immune CART cells before SCT: to bridge or not to bridge Patient 2: Patient ...
These patients represent a distinct, high-risk population that must be monitored for long-term transplant complications, including chronic GvHD (cGvHD), multi-organ dysfunctions and secondary malignancies. This article will review in a non-exhaustive manner, the approach to long-term care of an ...
For instance, a person with bone Avascular Necrosis (AVN), usually seen in cancer (CA) patients, may not be able to undergo open surgery. They are immunocompromised and have high risks for delayed healing, infections, and serious complications. ...
heterogeneity, tumour evolution and immune status; it is distinctly possible that the GM will become an increasingly central focus amongst them. The aim of this review is to provide clinicians with an overview of microbiome science and our current understanding of the role the GM plays in cancer...
The current standard for patients with advanced diffuse large B-cell lymphoma (DLBCL) is R-CHOP-21 (21-day rituximab-cyclophosphamidedoxorubicin- vincristine-prednisone). However, while this regimen cures approximately two-thirds of patients, a significant fraction of patients will still relapse, and...