The mRNA specific for NR1, NR2A and NR2B subunits is expressed in cerebellar Bergmann glia [88] and in cortical astroglia [89], whereas the immunoreactivity of NR1, NR2A and NR2B subunits was detected in the distal processes of cortical astrocytes [90]. Exposure of slice preparations to ...
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Alzheimer’s disease (AD) is a neurodegenerative disorder that is the most common cause of dementia and currently has few clinically efficacious disease modifying therapies [1]. In order to develop disease modifying therapies, it is imperative to better understand the mechanisms of disease initiation ...
aThere were indications that the astrocytes and Mu¨ller cells were experiencing stress because the expression of GFAP, which is induced after retinal damage,was increased. 有星形细胞和Mu¨ller细胞体验重音的征兆,因为,在视网膜损伤以后导致,增加了GFAP表示。[translate] ...
glial fibrillary acidic protein (GFAP), Iba1, or the proliferative marker, Ki-67. This outcome could be because 6 months could be too late to initiate probiotic treatment in the APPNL−G−Fmodel in which pathology is already quite severe at that age [85,86]. In contrast, Abdelhamid ...
GFAP III. III. Endogenous promoter I. Temporal specificity A. Inducible promoter B. ASO knockdown II. Cell and region specificity III. CNS vs peripheral apoE A. liver-specific expression B. VMC-specific expression C. liver-specific deletion I. ApoE2 overexpression II. ApoE lipidation inducers II...
The example of daclizumab illustrates quite well that there is no guarantee that a therapy which has been proven to be effective and safe for use in one condition, will work with the same safety profile in another condition. Daclizumab was initially developed as an intravenous therapy (Zenapax...
In particular, early biomarkers of structural damage, such as S-100B, GFAP, and UCH-L1 may be used to assist physicians in assessing a brain injury and determining whether to order a head CT scan for patient with a mild TBI. Markers become abnormal days or weeks after injury and could ...
In the absence of HH, PTC inhibits the signalling activity of the seven-pass transmembrane protein Smoothened (SMO); however, once PTC has bound HH, this inhibition is relieved and SMO can trigger an intracellular signalling cascade. Initial studies suggesting that PTC and SMO form a physical ...
Tissues were stained with antibodies against KLF7 (1 : 200; Novus Biologicals, Colorado, USA), peripheral myelin or P0 (1 : 200; Sigma-Aldrich, Missouri, USA), GFAP to identify astrocytes (1:200; Sigma-Aldrich), BDA to identify astrocytes (1:200; Sigma-Aldrich), SYP to identify presyna...