This case highlights a potential association of eosinophils in the CSF with autoimmune GFAP astrocytopathy, which may suggest its inclusion in the differential diagnosis of eosinophilic meningitis, encephalitis, or myelitis.doi:10.1016/j.jneuroim.2023.578249Mallory C. Lowe...
[17] Theroux LM, Goodkin HP, Heinan KC, et al. Extreme delta brush and distinctive imaging in a pediatric patient with autoimmune GFAP astrocytopathy[J]. Mult Scler Relat Disord, 2018, 26: 121-123. [18] Yang X,...
MyelitisMRIThe aim was to describe the clinical course and long-term outcomes of the French cohort of patients with glial fibrillary acidic protein (GFAP) astrocytopathy.#Patients with positive CSF GFAP antibody test were identified between May 2017 and February 2023. Those whose clinical ...
For example, previous published literatures showed that autoimmune GFAP astrocytopathy is an inflammatory disease of the central nervous system (CNS). Moreover, the studies of GFAP in brain tumors mainly focus on the predictive value of tumor volume. Furthermore, using biomarkers in the early ...
Longitudinally extensive myelitis in autoimmune glial fibrillary acidic protein astrocytopathy: A case report Chen Jinyu Liu Dejian Zhong Xinghua Peng Yu Wang Honghao Authors Info & Affiliations Published: 2022 -02 -26 · DOI: 10.3760/cma.j.cmcr.2022.e02417...
GFAP has been identified as an antigenic target of an inflammatory CNS disease, called autoimmune anti-GFAP astrocytopathy [2]. GFAP is also expressed in the peripheral nervous system (PNS) in non-myelinating immature Schwann cells and in satellite cells of dorsal root ganglia (DRG). It is ...
CSF analysis showed hypoglycorrhachia, pleocytosis, elevated ADA, and CSF-immunofluorescence characteristic of autoimmune GFAP astrocytopathy. MRI showed lesions at thalamus, corpus-callosum, dorsal pons and dentate nucleus with associated myelitis. Immunotherapy led to a full recovery, although MRI ...
Objective: We present a rare case of isolated headache with basal ganglia involvement on neuroimaging.Background: Autoimmune GFAP astrocytopathy is an inflammatory disease of the nervous system that typically presents as some combination of meningitis, encephalitis and myelitis. Symptoms include headache,...
Eight weeks after cyclophosphamide, he began visual tracking and following verbal commands.Conclusions: Our case suggests that cyclophosphamide, an alkylating agent that penetrates the blood brain barrier (BBB), should be considered for treatment of refractory GFAP astrocytopathy.Mohona Reza...
GFAP astrocytopathy can also manifest as fever, headache, and seizure, as well as lymphocytic pleocytosis in the CSF. Although the most frequent imaging finding is a striking pattern of linear perivascular radial enhancement on T1-weight post-gadolinium sequence, normal neuroimaging or leptomeningeal...