胶质纤维酸性蛋白是III类中间丝状体,存 在于中枢神经系统的星形胶质细胞、周围神经系统的无髓神经雪旺细胞和肠内成熟的胶质细 胞(enteric glial cells,EGCs) [4]。此外,GFAP在软骨细胞、成纤维细胞、 肌上皮细胞、淋巴细胞、肝星形细胞也有表达。 但有研究表明外周系统所表达的GFAP和中 枢神经系统的GFAP可能在结构...
GFAP-GFP expressing cells are found both in the border of the third ventricle and scattered throughout the parenchyma of the mediobasal hypothalamus.Rates of hypothalamic neurogenesis show no sexual dimorphism, in contrast to canonical niches.GFAP-positive glial cells are a major source of ...
Cultures of cells immunoreactive for glial fibrillary acidic protein (GFAP), as well as for the intermediate filament marker nestin were grown in a medium including epidermal growth factor (EGF) and serum. The cultured cells had the morphology of astroglial cells. The cells can be proliferated in...
We show that GFAP + progenitor cells give rise to neurons and oligodendrocytes throughout the CNS. We find very little regional heterogeneity in the neurogenic potential of radial glia between dorsal and ventral telencephalon. Additionally, radial glia serve as precursors for subpopulations of ...
In addition, neural stem cells strongly express GFAP. Antibodies to GFAP are very useful as markers of astrocytic cells. In addition, many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver...
coli cells. It contains AA Met 1 - Met 432 (Accession # P14136-1). Predicted N-terminus: Met 蛋白结构(Molecular Characterization) This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 51.9 kDa. The protein migrates as 50 kDa under reducing (R...
GFAP has been shown to be involved in astrocyte functions, which are important during regeneration, synaptic plasticity and reactive gliosis. It is used as a marker to distinguish astrocytes from other glial cells during development. GFAP;GFAP抗体;多克隆GFAP;百普赛斯;ACRO;...
GFAP is a marker for mature glial cells. This antibody is polyclonal and was raised in rabbit to the peptide sequence – NAGFKETRASERAE (human, rat and mouse) – that was coupled to thyroglobulin by glutaraldehyde before being injected into the rabbit. The antibody has been used for ...
(CNS) including astrocytes and ependymal cells. GFAP has also been found to be expressed in glomeruli and peritubular fibroblasts, Leydig cells of the testis, keratinocytes, osteocytes and chondrocytes and stellate cells of the pancreas and liver. GFAP is a type III IF protein that is closely ...
It is predominantly found in the astrocytes which are the most abundant subtypes of glial cells in the brain and spinal cord. As a marker protein of astrocytes, GFAP may exert a variety of physiological effects in neurological diseases. For example, previous published literatures showed that ...