One important function of endothelial cells in glioblastoma multiforme (GBM) is to create a niche that helps promote self-renewal of cancer stem-like cells... TS Zhu,MA Costello,CE Talsma,... - 《Cancer Research》 被引量: 332发表: 2011年 Cancer stem cell dynamics in tumor progression and...
Since GBM is one of the most aggressive types of cancer, relative survival estimates are quite low, with only 5.1% of patients surviving 5 years after diagnosis [2]. The optimal treatment for GBM consists of the combination of surgical resection, radiation therapy, and chemotherapy [3–5]. ...
It is currently being investigated in a phase II study for patients with recurrent GBM where an ultrasound device is implanted at the level of an excised bone window after Summary Neuro-oncology remains dynamic and exciting. This review has attempted to highlight key studies that have affected ...
Single-cell RNA sequencing (scRNA-seq) is a tool for studying gene expression at the single-cell level that has been widely used due to its unprecedented high resolution. In the present review, we outline the preparation process and sequencing platforms
Glioblastoma (GBM) is the most prevalent type of malignant tumor within the central nervous system. There is a growing demand to develop and adapt new therapeutic options in order to combat the five-year survival rate of 6.8% and improve patient quality of life. Arsenic trioxide (ATO) is ...
Alzheimer’s disease (AD), the most common cause of dementia, results in a sustained decline in cognition. There are currently few effective disease modifying therapies for AD, but insights into the mechanisms that mediate the onset and progression of di
A new analysis from the radiation group at the International Agency for Research on Cancer (IARC) calls into question the agency’s own classification of wireless radiation as a possible human carcinogen.On May 27, IARC’s Isabelle Deltour presented the
Chemical formula is that of mibefradil. TTCCs and the RAF/RAS/MAPK pathway: A second positive feedback mechanism for cancer cell proliferation and survival? Of the above-mentioned possibilities, the existence of a TTCC–extracellular signal-regulated kinase (ERK) axis has been reported in ...
Alzheimer’s disease (AD), the most common cause of dementia, results in a sustained decline in cognition. There are currently few effective disease modifying therapies for AD, but insights into the mechanisms that mediate the onset and progression of di
Bosland,MC - 《Cancer Prevention Research》 被引量: 11发表: 2016年 Molecular Targeted Therapy in Enteropancreatic Neuroendocrine Tumors: From Biology to Clinical Practice Over the last ten years, several molecular targeted agents (MTAs) have been studied in phase II trials, and very few of them...