It is currently being investigated in a phase II study for patients with recurrent GBM where an ultrasound device is implanted at the level of an excised bone window after Summary Neuro-oncology remains dynamic and exciting. This review has attempted to highlight key studies that have affected ...
surgical treatment—a systematic review Lei Wang1,3†, Buqing Liang2†, Yan Icy Li1,4, Xiang Liu1, Jason Huang2 and Yan Michael Li1* Abstract Glioblastoma multiform (GBM) is the most common malignant brain tumor characterized by poor prognosis, increased invasiveness, and high relapse ...
Therefore, understanding the functional status of individual tumor cells and recognizing cell subset composition and characteristics is of great significance for cancer biology and treatment strategies (Table 1 (see Additional file 2)). Glioblastoma (GBM) is the most common primary malignant brain tumor...
Glioblastoma (GBM) is the most common type of primary brain cancer and carries a dismal prognosis primarily due to the emergence of resistance towards extant radiation, conventional and targeted chemotherapies. Although GBM resists therapy-induced apoptosis, tumors show a seemingly paradoxical propensity...
With the recent approval by the FDA of an immunotherapy for prostate cancer and another positive immunotherapy trial in melanoma, immunotherapy may finally be coming of age. So what will it take for it to become part of the standard treatment for glioblastoma? To put this question into perspecti...
Deltour states that the reliability of her analysis is dependent on the “completeness” of the cancer registry data (slide 34). But at least for Sweden, the Nordic country with the largest population and the most cases of brain tumors, the cancer registry has been shown to be substantially...
such as inflammatory bowel disease [112] andClostridium difficileinfection [113]. Additionally, bacteria have been engineered to release anti-cancer therapies [114,115,116]. This class of therapeutics likely would also be beneficial in brain diseases in which the GMB is involved, such as AD, PD...
Others have reported that expression of CRP in the cytosol of GBM tissues was lower than that in the cytosol of noncancerous brain tissues, suggesting that degraded CRP in GBM tissues is exported into the circulation[25]. In a mass spectroscopy analysis of 15 GBM patients versus 14 controls ...
The etiology of childhood cancers has been studied for more than 40 years. However, most if not all cancers occurring in children are attributed to unknown causes. This review is focused on the role of infections in cancer development and progression in children. The main infectious agents includ...
Direct administration of chemotherapy to the CSF is not being used. In contrast, whenever a systemic tumor seeds the subarachnoid space the standard approach includes intensive intra-CSF chemotherapy, radiotherapy to limited or extended CNS fields and various combinations of systemic chemotherapy. The ...