Pregnancy and C1 esterase inhibitor deficiency: a successful outcome (C1INH) deficiency was managed successfully in our department and her management was a part of a shared care strategy with the medical and anesthetic ... F Nathani,H Sullivan,D Churchill - 《Archives of Gynecology & Obstetrics...
It is well known that C1q deficiency in man and experimental gene knock-out animals leads to a severe form of systemic lupus-like disease[87]. Inhibitors of C3 convertase FUT-175 (nafamstat) is a potent synthetic serine protease inhibitor. It has potent anti-complement activity in vitro. It...
In addition, a PDGFR inhibitor, dasatinib, partially reverses cancer-promoting CAFs to resting- state fibroblasts in lung adenocarcinoma (LUAC) and is a potential therapeutic strategy for LUAC [87]. Fibroblast‑specific protein 1 Fibroblast-specific protein 1 (FSP-1) belongs to the S100 small ...
For this blood test, blood will be drawn from the vein in your arm and siphoned into a special tube for laboratory testing. The blood is tested for hemoglobin levels in the red blood cells, which can help your doctor if you have anaemia caused by iron deficiency. Iron produces the molecu...
Dwarfism in plants can be produced by a deficiency in one or more endogenous hormones, including GA, BR, IAA, and CK (Table 1). GA is one of the most important phytohormones controlling PH, both alone and in conjunction with other hormones. Table 1. Dwarf genes involved in plant hormone...
Ziahosseini K, Ali S, Simo R, Malhotra R.Uvulitis following general anaesthesia.Case Reports. 2014;2014(sep23 1):bcr2014205038-bcr2014205038. doi:10.1136/bcr-2014-205038 Frank M, Zuraw B, Banerji A et al.Management of Children With Hereditary Angioedema Due to C1 Inhibitor Deficiency.Pediatr...
Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter. Nature Genet. 21, 91–94 (1999). CAS PubMed Google Scholar Tang, N. L. et al. Mutations of OCTN2, an organic cation/carnitine transporter, lead to deficient cellular ...
Epithelial-to-Mesenchymal Transition is a Cause of Both Intrinsic and Acquired Resistance to KRAS G12C Inhibitor in KRAS G12C–Mutant Non–Small Cell Lung Cancer. Clin. Cancer Res. 2020, 26, 5962–5973. [Google Scholar] [CrossRef] Cannataro, V.L.; Gaffney, S.G.; Stender, C.; Zhao...
Modified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo. The use of MVA and MVA-vectored vaccines against human and animal diseases must comply with regulatory requirements as they pertain to env...
The report provides comprehensive information on the therapeutics under development for Hereditary Angioedema (HAE) (C1 Esterase Inhibitor [C1-INH] Deficiency), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. He...