What Is the Pathobiology of Inflammation to Cell Death? Apoptosis, Necrosis, Necroptosis, Autophagic Cell Death, Pyroptosis, and NETosisImmunogenic cell deathTolerogenic cell deathInflammationImmunityDAMPCell d
Autophagic cell death was also observed in in vitro cultures of adult hippocampal neural cells in response to insulin removal (PMID: 18653772; (5)). The main characteristic of autophagy-dependent cell death is extensive autophagic vacuolization of the cytoplasm, with no changes in chromatin ...
The therapeutic potential of autophagy for the treatment cancer and other diseases is beset by paradoxes stemming from the complexity of the interactions between the apoptotic and autophagic machinery. The simplest question of how autophagy acts as both a protector and executioner of cell death remains...
Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1. Leukemia Res 2007; 31: 329–339. Google Scholar Isakson P, Bjoras M, Boe SO, Simonsen A . Autophagy contributes to therapy-induced degradation of the PML/RARA ...
is a natural and useful process for longevity. Intermittent fasting can lead to the induction of adaptive autophagy and increase the longevity of eukaryotic cells. However, prolonged calorie restriction with excessive autophagy response is harmful and may stimulate a type II autophagic cell death. ...
Ltn1 is a key player in the ribosome-associated protein quality control (RQC) pathway, which in an Ubp3-antagonistic manner protects the 60S from autophagic turnover.35 Proteins in the RQC pathway facilitate the removal of ribosomes on stalled mRNAs by first splitting the 80S ribosome releasing...
Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity. Journal of Lipid Research 56: 546–561. doi:10.1194/jlr.M055152. Article CAS PubMed PubMed Central Google Scholar Jaiswal, A.K. 2004. Nrf2 signaling in coordinated activation of antioxidant gene ...
. The number of autophagic vacuoles increased in neurons in the brain regions of PD patients. This result indicates that the autophagy of neurons in the brains of PD patients is higher than that of the healthy population [182]. Koo et al. found that running exercise promotes autophagic ...
Pavlides S, Tsirigos A, Migneco G, Whitaker-Menezes D, Chiavarina B, Flomenberg Net al. The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism.Cell cycle2010;9: 3485–3505. ...
It has been confirmed that when bile acid is used to treat chronic cholestatic liver disease (CCLD), UDCA induces a sarcoptic-like phenotype with degraded protein synthesis and autophagic flux [64]. It's paramount, therefore, to contemplate the potential adverse effects on skeletal muscles when ...