47,48]. SGLT-2 inhibitors exert a wide range of pleiotropic actions, some of which may prove as important future targets of therapy. SGLT-2 inhibitors reduce glycolysis, rebalance the coupling between glycolysis and oxidative
47,48]. SGLT-2 inhibitors exert a wide range of pleiotropic actions, some of which may prove as important future targets of therapy. SGLT-2 inhibitors reduce glycolysis, rebalance the coupling between glycolysis and oxidative
et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1, 555–567 (2007). Article CAS PubMed PubMed Central Google Scholar Carpentino, J. E. et al. Aldehyde dehydrogenase-expressing colon stem cells ...
One of the most consistent co-morbidities associated with worse outcome in COVID-19 patients is diabetes, along with age and cardiovascular disease. Studies on the association of diabetes with other acute respiratory infections, namely SARS, MERS, and Influenza, outline what seems to be an ...
It was something to the wording of, “Look, we have to let you know- we think this is just a prank- but someone sent an anonymous note to the school saying, (blah blah, however he phrased it) and we need to take precautions…” Whereupon, instead of playing it cool, my “closest...
and Europe Methods: We have analyzed a prospectively enrolled cohort of forty-eight patients with HL who were diagnosed in two large university medical centers from 5/2015 to 2/2018. All pts have undergone pretreatment FDG-PET/CT with quantitative analysis of TMTV, Total Lesion Glycolysis (TLG)...
Fig. 3. Effect of reduced uterine perfusion pressure (RUPP) surgery on (A) fetal viability, (B) fetal weight and (C) placental weight. Each row represents an individual study, or multiple studies observing the same outcome. Bar colour indicates change in viability, fetal weight or placental ...
P: Schedule STAT vascular sonogram of lower extremities; pt is to keep the leg elevated x 2d then RTC for follow-up and test result on Thursday (or sooner if ↑ edema, SOB, or CP). What one word in the patient's chart note gives the answer...
In terms of therapy, it is important to know which trajectory a particular carcinoma will follow because of tangible opportunities for drugs to reroute cellular fates towards the first or at least second outcome. These mathematical models have a distinct advantage over clinical observations and cell ...
Accordingly, the TME is closely related to the diverse biological behaviors of tumors [1–3]. Cancer-associated fibroblasts (CAFs) are an impor- tant component of the tumor stroma. CAFs interact with tumor cells in various ways, such as by remodeling the ECM and secreting cytokines and ...