Genetic risk is a very powerful predictor that can explain large variations in disease incidence. A polygenic risk score for a disease can be a more powerful risk factor than all other risk factors combined. The possibility of a single test measuring susceptibility to many common diseases ...
are important determinants of uptake. “Effectively communicating that a high-risk score does not mean that someone will definitely develop a condition, and that a low score does not mean that they will remain disease free, is key to driving the adoption of healthy behaviours,” he says...
Cascade screening following a polygenic risk score test: what is the disease risk of a sibling conditional on a high score of a proband? 来自 Semantic Scholar 喜欢 0 阅读量: 15 作者: S Carmi 摘要: Polygenic risk scores (PRSs) for predicting disease risk have become increasingly accurate, ...
In the scientific literature, the resulting score is typically presented as an odds ratio.If a PRS is making a health-related claim, it requires all the same evidence that is required of any other clinical test before it can be legally marketed. Similarly, a PRS...
Zheutlin, A. B., and Ross, D. A. (2018). Polygenic risk scores: What are they good for? Biol. Psychiatry 83, e51-e53. doi: 10.1016/j.biopsych.2018.04.007Zheutlin, A. B. and Ross, D. A. (2018). Polygenic risk scores: What are they good for? Biological Psychiatry 83, e51-...
The extent to which genetics plays a role in intelligence has long been a matter for debate. However, it is now well established that genetic effects can c... SJ Knight - John Wiley & Sons, Ltd 被引量: 11发表: 2008年 What can Neuropsychology Teach Us About Intellectual Disability? In ...
No One Is Going to Tell You Feb 25, 2021 BioPharma Reporter German program using whole genome sequencing to diagnose rare diseases and cancer risk Feb 17, 2021 Cambridge Independent Illumina Accelerator Cambridge announces four chosen genomics start-ups and £20m match-funding pledge Feb 17, ...
Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies We report a new model to project the predictive performance of polygenic models based on the number and distribution of effect sizes for the underlying sus... N Chatterjee,B Wheeler,J Sampson...
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Preliminary findings from a new study involving more than 6,000 adults found that taste-related genes may play a role in determining food choices and could, in turn, influence cardiometabolic health. It is one of the first studies to examine how the gene