Thus, we included direct measurements of genetic risk (e.g. schizophrenia polygenic risk scores) in causation models to assess the extent to which cognitive deficit mediates some of the effect of polygenic risk scores on the disorder. Causal models of family data tested relationships among key ...
The concept of a polygenic risk score (PRS) had been circulating among researchers for several years. It wasn’t until 2018, however, that these scores were shown to have potential for broad-scale clinical use. A study by Amit V. Khera and colleagues at the Cardiovascular Disease Initiative ...
found all transcripts to be affected post-treatment (p < 0.05). Lithium may therefore confer its anti-ageing effects by moderating the expression of genes responsible for normal telomere length regulation. This is supported by our bipolar disorder sample, which shows that polygenic risk scores ...
This may be explained through sex-specific hormonal-related pathways being involved in the overlap of endometriosis with these traits. Pain is an incentive to seeking an endometriosis diagnosis, so in addition to the endometriosis genetic risk signals capturing variants associated with lesion growth, ...
In addition to normalized multiplicative polygenic risk scores and rank in a population, the disease prevalence and proportion of heritability explained by ... S Won,Kong,In-Hee,... - 《Genetics in Medicine Official Journal of the American College of Medical Genetics》 被引量: 37发表: 2015年...
Polygenic risk scores (PRS) have successfully summarized genome-wide effects of genetic variants in schizophrenia with significant predictive power. In a clinical sample of first-episode psychosis (FEP) patients we estimated the ability of PRS to discriminate case-control status and predict the developm...
Associations between polygenic risk scores for ASD and the secondary MRI phenotypes, Sub-regional Volumes. Bar charts of variance explained by ASD PRS (R2, y-axis) constructed at each of seven probability thresholds (0.001 ≥ PSNP≤1, x-axis), for each of the twenty-eight cerebellar re...
Attention-Deficit/Hyperactivity Disorder Polygenic Risk Scores Predict Attention Problems in a Population-Based Sample of Children 来自 国家科技图书文献中心 喜欢 0 阅读量: 17 作者:Groen-Blokhuis,M Maria,Neale,M Ben,Boomsma,I Dorret,Hudziak,J James,Kees-Jan,Davies ...
Polygenic Risk Scores (PRS) for AD offer unique possibilities for reliable identification of individuals at high and low risk of AD. However, there is little agreement in the field as to what approach should be used for genetic risk score calculations, h
In the same target sample, LNL-ISO explained more variance in schizophrenia risk than loneliness (R2 (95% CI) = 0.41% (−0.08, 0.89) at Pthreshold = 0.05, p = 1.42 × 10−3; Fig. 2A). The contribution of PGSLNL-ISO to schizophrenia risk was also higher than ...