MASLD metabolic dysfunction-associated steatotic liver disease, PRS polygenetic risk score Full size image Fig. 3 The impact of MASLD on SLD and extrahepatic outcomes. The hazard ratios were obtained from model 2 with the non-MASLD as the reference group. “Overall” refers to the whole MASLD...
Using a de-identified mirror of medical center's electronic health record, we applied published algorithms for T1D and T2D to identify cases, and used natural language processing and chart review strategies to identify cases of maturity onset diabetes of the young (MODY) and other more rare ...
Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available ...
Flow chart of the prognostic model in this study. ), this study included 450 patients with NMBC who received radiotherapy. Based on the limma differential analysis between 1,091 tumor tissues and 113 non-tumor tissues downloaded from TCGA, 447 up-regulated genes and 1,082 down-regulated genes...
The size of pie chart sections indicating the number of included outcomes: biochemical measures (167), cognition and mental health (223), disease diagnosis (1430), health and medical history (270) and sociodemographics (152). Full size image Results Phenotypes associated with TS The study include...
Table 1 Polygenic risk score (PRS) of ulcerative colitis (UC) and Crohn’s disease (CD) as a predictor of time to development of all-grade and severe immune checkpoint inhibitor-mediated colitis (IMC) in the entire GeRI cohort, using Cox proportional hazards models and stratified analysis asse...
These SNVs can be combined to generate a Polygenic Risk Score (PRS), which estimates an individual's risk to develop prostate cancer. Identifying individuals at higher risk for prostate cancer using PRS could allow for personalized screening recommendations, improve current screening tools, and ...
A DCM polygenic score comprising 2.3 million common genetic variants associated comparably with DCM and all three secondary cardiomyopathies (meta-analyzed p<0.001 for all) (\nFigure\n). Among chart-validated phenotypes in MGB Biobank, cases had higher median polygenic score percentiles than ...
Polygenic risk scores (PRS) have shown promise in predicting human complex traits and diseases. Here, we present PRS-CS, a polygenic prediction method that infers posterior effect sizes of single nucleotide polymorphisms (SNPs) using genome-wide associat
A flow chart of pKWmEB method Full size image Genome-wide efficient mixed model association This is an existing GWAS method (Zhou and Stephens 2012) and used as a gold standard for comparison. This method is the fixed model version of the original MLM, in which βi was treated as fixed ...