SrinivasNuggehally R.Springer Berlin HeidelbergCancer Chemotherapy & PharmacologySrinivas, N. R. (2016). Understanding the role of tariquidar, a potent Pgp inhibitor, in combination trials with cytotoxic drugs: what is missing? Cancer Chemother. Pharmacol. 78, 1097-1098. doi: 10.1007/s00280-016-...
PURPOSE: The purpose of this study was to investigate the safety and tolerability of Zosuquidar.3HCl, a potent inhibitor of P-glycoprotein (Pgp), when admi... EH Rubin,DP de Alwis,I Pouliquen,... - 《Clinical Cancer Research》 被引量: 276发表: 2002年 Mechanisms of antibody-dependent ...
An additional layer of complexity is various subpopulations of memory CD4+ T cells generated in the course of a primary immune response [7,8]. Because of the common origin of T helper cells and regulatory T (Treg) cells (Box 1), it seems logical that the formation of memory Treg cells ...
As OPG is an inhibitor of RANKL, the increase in the RANKL-OPG ratio favors osteolytic lesions [42]. RANKL is secreted by breast cancer cells in response to progesterone [62,63], although this mechanism has not been directly implicated in osteolysis. VEGF expression is present at high ...
Of them, AphA (PDB ID: 1YG2), AphB (PDB ID: 3SZP), LuxO (Uniprot ID: Q9KT84), TcpA (PDB ID: 3HRV), VpsT (PDB ID: 3KLN) and VpsR (Uniprot ID: Q9AQ41) were selected for our docking studies. Resveratrol--a potential inhibitor of biofilm formation in Vibrio cholerae BLIND,...
Dramatic response to cyclin D-dependent kinase 4/6 inhibitor in refractory poorly differentiated neuroendocrine carcinoma of the breast The tumor cells of the polypoid tumors were positive for pancytokeratin, synaptophysin, chromogranin A, CD57, protein gene protein 9.5 (PGP9.5), and Ki67 (2% of ...
The functionality of all components of auxin signalling and homeostasis is essential for proper plant development. The cellular presence of an endogenous or exogenous (e.g., synthetic) auxin is perceived by the TRANSPORT INHIBITOR RESPONSE1/AUXIN SIGNALING F-BOX (TIR1/AFB) signalling pathway, and...