In addition, the study identified the natural compound isoliquiritigenin (ISL) as an inhibitor that targeted ABCA1 and significantly reduced CRC metastasis induced by PGC-1 & alpha;. Overall, this study sheds light on how PGC-1 & alpha; promotes CRC metastasis by regulating ABCA1-mediated ...
Furthermore, + cells with reduced expression of -1α or when treated with , a pharmacological inhibitor of α, exhibit diminished expression of genes. The biological relevance of the control of genes by the -1α/α axis is demonstrated by consequent regulation of glutamine flux through the . ...
Here we show that Ang II stimulation increases serine phosphorylation of PGC-1 (2.2 folds) with a peak at 15 min, which is inhibited by LY294002 , a specific PI3 kinase inhibitor (98% decrease), and by Akt inhibitor-2/Triciribine (95% decrease). Ang II promotes PGC-1 phosphorylation ...
Hepatic insulin sensitivity was enhanced in PGC-1-deficient mice, reflecting in part the reduced expression of the mammalian tribbles homolog TRB-3, a fasting-inducible inhibitor of the serine-threonine kinase Akt/PKB (ref. 6). We show here that, in the liver, TRB-3 is a target for PPAR...
PROBLEM TO BE SOLVED: To obtain a PGC-1α (Peroxisome proliferator activated receptor γ coactivator 1α) expression promoter through a selective β receptor and a PGC-1α expression inhibitor through a β receptor and to provide a method for using them.MIURA SHINJI...
The pgc-1.alpha. Biosynthetic promoter and slow slow muscle contraction inhibitor in accordance with the present invention are characterized by including Enterococcus sp. as an effective ingredient.藤野 英己立垣 愛郎
We examined the effects of empagliflozin, a selective inhibitor of Na+-glucose cotransporter 2, on mitochondrial quality control and autophagy i... HL Yu,HK Sang,JM Kang,... - 《American Journal of Physiology Renal Physiology》 被引量: 0发表: 2019年 Mitochondrial biogenesis during seed germinat...
Inhibition of mitochondrial fission with Drp1 inhibitor mdivi-1 suppressed oxidative stress, alleviated mitochondrial dysfunction and cardiac dysfunction in diabetic mice. These findings show that melatonin attenuates the development of diabetes-induced cardiac dysfunction by preventing mitochondrial fission ...
The invention discloses application of a cembranoid diterpene flexibilide or medicinal salt thereof in preparation of a PGC-1 alpha (peroxisome proliferator-activated receptor-gamma coactivator-1 alpha) inhibitor. The flexibilide of the invention has strong PGC-1 alpha inhibitory activity, and the ...
And after AMPK agonist AICAR and inhibitor Compound C intervention, Fasting blood glucose, fasting insulin and testosterone levels were observed. The HOMA index was calculated. The changes of PGCα expression in ovarian tissue were observed by western blot and immunohistochemistry to determine the ...