P-GlycoproteinPhosphatesCarrier Proteins双嘧达莫肾小管, 近端P-糖蛋白磷酸盐类P-glycoprotein inhibitors stimulate renal phosphate reabsorption in rats. Background. Dipyridamole (Dip) was previously shown to increase renal phosphate (Pi) reabsorption in humans. However, the mechanism(s) underlying this ...
近日,浙江工业大学王鸿课题组在国际知名药物化学期刊European Journal of Medicinal Chemistry在线发表以“Design, synthesis and biological evaluation of novel phenylfuran-bisamide derivatives as P-glycoprotein inhibitors against multidrug resistance in MCF-7/ADR cell”为题的研究论文(DOI: 10.1016/j.ejmech.2023....
2) P-glycoprotein inhibitors P-糖蛋白抑制剂 1. So far there have been three generations of P-glycoprotein inhibitors reported with a mechanism of increased accumulation of anti-tumor agents in MDR cells. 开发安全高效的P-糖蛋白抑制剂一直被认为是攻克MDR难题的有效途径,至今已经被研究了30多年;...
近日,浙江工业大学王鸿课题组在国际知名药物化学期刊European Journal of Medicinal Chemistry在线发表以“Design, synthesis and biological evaluation of novel phenylfuran-bisamide derivatives as P-glycoprotein inhibitors against multidrug resistance in MCF-7/ADR cell”为题的研究论文(DOI: 10.1016/j.ejmech.2023....
P-glycoprotein inhibitorsbioavailabilitymultidrug resistanceocular diseaseIntroduction: P-glycoprotein is a complex ATP-ase transporter involved in physiological and pathological functions. In particular, it is involved in the onset of multidrug resistance in cancer, in ocular disease, Chronic Rhinosinusitis, ...
6. Jump up to:abResearch,Center for Drug Evaluation and."Drug Interactions&Labeling-Drug Development and Drug Interactions:Table of Substrates,Inhibitors and Inducers".www.fda.gov.Retrieved 2018-11-30. 7. Srivalli,KMR;Lakshmi,PK(July 2012)."Overview of P-glycoprotein inhibitors:a rational outloo...
In recent years, an extraordinary array of highly potent, selective, and low-toxicity P-gp inhibitors have been reported. Herein, we provide a comprehensive review of the synthetic and natural products that have specific inhibitory activity on P-gp drug efflux as well as promising chemosensitizing...
Bthat the sensitivity of the MDR cell line to chemotherapeutics was increased by several orders of magnitude in the presence of the P-gp inhibitors. Inclusion of the BCRP inhibitor, novobiocin, or the MRP-1-inhibitor, probenecid, had no discernable effect on these cells (Table1), suggesting ...
However, the role of this transporter in drug–drug interactions is still poorly studied even though a lot of P-glycoprotein substrates and P-glycoprotein inhibitors are identified among drugs of standard usage. On one hand, Pgp is distributed within a lot of organs and tissues implicated in ...
Enzyme InhibitorsP-GlycoproteinProtein Kinase CAffinity LabelsAzides酶抑制剂P-糖蛋白蛋白激酶CP-glycoprotein is a membrane ATPase that transports drugs out of cells and confers resistance to a variety of chemically unrelated drugs (multidrug resistance). P-glycoprotein is phosphorylated by prote...