What does this new variant mean for vaccine effectiveness? If we look at the smallpox vaccine, we never saw resistance evolve to it. It's the same for measles, polio and themajority of vaccinesthat we have. We never have to update them, and they just keep working. But there have been...
2. Generalizability: Effective for more than healthy volunteers.As a general rule, it’s well known that formal study “efficacy” of a health intervention (as observed in controlled conditions) does not always predict real-world “effectiveness” in non-random, less ideal conditions. As an exam...
far too many vaccines never get tested in the context of aged immune systems until Phase 2 and 3 clinical trials. The time to find out that a vaccine does not work well in the context of immunosenescence is not at this extremely late stage, when it is too late to fix the problem. Thi...
Vaccine effectiveness in older individuals: What has been learned from influenza-vaccine experience. Ageing Res Rev. 2011; 10 (3):389–395.Lang PO, Govind S, Mitchell WA, Siegrist CA, Aspinall R (2011) Vaccine effectiveness in older individuals: what has been learned from the influenza-...
spike that are “good” for the virus right now could also make it less fit in the context of population-level immunity in the future. Defining these dynamics, and their potential influence on vaccine effectiveness, will require large-scale monitoring of SARS-CoV-2 evolution and host immunity ...
When Will the COVID-19 Vaccine Be Approved for Kids? Pfizer, which produced the first COVID-19 vaccine to gain full FDA approval, is the furthest along in the process. The company last month submitted data to the FDA on the effectiveness of its shot in children ages 5-11. Th...
What does infographic mean? An infographic is a visual tool that combines images, charts and text to present information clearly and engagingly. Infographics simplify complex ideas, making them easy to understand at a glance. What is an infographic example?
However, vaccine efficacy does not always predict vaccine effectiveness—ie, the protection attributable to a vaccine administered non-randomly under field conditions.11 For example, the effectiveness of rotavirus vaccines in children in low-income and middle-income settings was lower than the efficacy ...
it does not mean that a certain vaccine can be produced easily. Production processes for vaccines are complicated, reagents need to be available in a certain quality (good manufacturing practice (GMP) quality), and small changes in any process parameters may have a huge impact and could necessit...
Finally, Does the vaccine protect humans in the real world? That is called "vaccine effectiveness." The difference between efficacy and effectiveness is that in efficacy studies, the conditions and subjects are chosen to be ideal for the study. Effectiveness means that the vaccine protects people ...