Progress of the COVID-19 vaccine effort: viruses, vaccines and variants versus efficacy, effectiveness and escapeWhere 2020 saw the development and testing of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at an unprecedented pace, the first half of 2021 has seen ...
efficacy in laboratory conditions does not always translate to effectiveness in the real world due to virus factors and host factors, such as age, comorbidities (including frailty/function), prior exposure, and priorvaccination[1–4]. Vaccine effectiveness studies are of particular importance in highe...
Vaccine safety versus vaccine efficacy in mass immunisation programmes The findings suggest that it may not always be in the interests of the community to use the vaccine with the lowest complication rate. DJ Nokes,RM Anderson - 《Lancet》 被引量: 47发表: 1991年 Safety and immunogenicity of ...
We have focused on the evolution, multiple mutants, waves of the SARS-CoV-2, and different marketed vaccines undergoing various clinical trials and the design of the trials to determine vaccine efficacy. Conclusion Various mutants of SARS-CoV-2 arrived, mainly concerned with the spike protein, a...
Double negative control inference in test-negative design studies of vaccine effectiveness. ArXiv. 2023. Hatton P. The use of the screening technique as a method of rapidly estimating vaccine efficacy. Public Health. 1990;104(1):21–5. Article CAS PubMed Google Scholar Farrington CP. ...
The baseline configuration results in estimates of 63% for both overall and direct effectiveness with vaccine efficacy α assumed to be 70%. Figure 1 presents the impact of variation of a single parameter on overall and direct vaccine effectiveness with other parameters held at their fixed baseline...
VE is calculated by (1 − RR) × 100), where RR is the relative risk of a disease outcome in the vaccinated group compared to the unvaccinated group. Vaccine efficacy is measured in randomized controlled trials, whereas vaccine effectiveness is obtained from observational studies. VE...
Objective: We aimed to investigate whether individuals' trade-offs between vaccine effectiveness and vaccine safety vary if they are asked to consider the perspective of a policymaker making decisions for others compared with the decisions they would make for themselves. Method: A web-enabled discrete...
Vaccinia immunization is cross-protective against other orthopoxvirus infections, includingvariola. Preexposurevaccine efficacyis estimated to be as high as 100% for 1 to 3 years after vaccination,40and reports from thesmallpox eradicationefforts noted that “smallpox rarely occurs during the 4 or ...
Access: The patient's ability to obtain vaccines Confidence &Trust: Safety and efficacy of vaccination Affordability: The patient's ability to afford vaccines or have the time to obtain vaccines Complacency: Perception of low risk and disease severity Awarness: The patient's ability to understa...